Determinants of thromboxane biosynthesis in patients with moderate to severe chronic kidney disease

Natale Vazzana, Francesca Santilli, Stefano Lattanzio, Mario Liani, Luciano Giacci, Goffredo Del Rosso, Filippo Salvati, Andrea Boccatonda, Patrizia Ferroni, Giovanni Davì

Research output: Contribution to journalArticle

Abstract

Background: Mechanisms of accelerated atherothrombosis in patients with chronic kidney disease (CKD) are only partly characterized. The aims of this study were to evaluate the extent of thromboxane (TX)-dependent platelet activation in patients with CKD, and to characterize the determinants of altered TX biosynthesis in this setting, with particular reference to enhanced lipid peroxidation, low grade inflammation and CKD-related anemia. Patients and methods: A cross sectional comparison between urinary 8-iso-PGF and 11-dehydro-TXB2, in vivo markers of oxidative stress and platelet activation, respectively, was performed in 115 patients with stage 1-4 CKD. Results: Levels of both urinary 11-dehydro-TXB2 and 8-iso-PGF increased sequentially across the four CKD stages (P2 and 8-iso-PGF (Rho=0.620, P2α (β=0.459, P2 (adjusted R2 =0.488). Conclusions: This study provides biochemical evidence of persistent platelet activation in patients with CKD. This condition occurs early in the natural history of the disease and is related to kidney function and oxidative stress. Moreover, we found an independent inverse relationship between hemoglobin levels and TX-dependent platelet activation. This finding may provide a mechanistic link between CKD-related anemia and increased cardiovascular risk.

Original languageEnglish
JournalEuropean Journal of Internal Medicine
DOIs
Publication statusAccepted/In press - May 23 2016

Keywords

  • 11-dehydro-TXB
  • 8-iso-PGF
  • CKD
  • EGFR
  • Prostanoids

ASJC Scopus subject areas

  • Internal Medicine

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    Vazzana, N., Santilli, F., Lattanzio, S., Liani, M., Giacci, L., Del Rosso, G., Salvati, F., Boccatonda, A., Ferroni, P., & Davì, G. (Accepted/In press). Determinants of thromboxane biosynthesis in patients with moderate to severe chronic kidney disease. European Journal of Internal Medicine. https://doi.org/10.1016/j.ejim.2016.06.016