Determination of albuminuria in type 1 and type 2 diabetic patients with microproteinuria and overt nephropathy. Comparative evaluation between a radial immunodiffusion procedure and a highly sensitive radioimmunoassay

Marisa Fioravanti, Sebastiano Bruno Solerte, Anna Linda Patti, Luisa Bacchella, Maria Grazia Zanoletti, Donatella Mancin, Nicola Schifino, Carlo Aprile, Ettore Ferrari

Research output: Contribution to journalArticlepeer-review

Abstract

We have studied the correlation between urinary albumin excretion rate evaluated by a radial immunodiffusion technique and a highly sensitive radioimmunoassay in type 1 and type 2 diabetic patients with microproteinuria and overt clinical nephropathy. Several statistically significant correlations were found between urinary albumin excretion rate measured by radial immunodiffusion and by radioimmunoassay, both in patients with microproteinuria and overt nephropathy. Moreover, statistically significant correlations between urinary albumin excretion rate, albumin clearance and total urinary protein excretion rate were observed in each of the groups studied. The radial immunodiffusion procedure can therefore be considered a useful and sensitive method for the evaluation of urinary albumin excretion rate both in diabetic patients with microproteinuria and in patients with overt clinical nephropathy.

Original languageEnglish
Pages (from-to)171-179
Number of pages9
JournalLa Ricerca in Clinica e in Laboratorio
Volume17
Issue number2
DOIs
Publication statusPublished - Apr 1987

Keywords

  • Albuminuria
  • Insulin-dependent diabetes mellitus
  • Microproteinuria
  • Nephropathy
  • Non-insulindependent diabetes mellitus

ASJC Scopus subject areas

  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Determination of albuminuria in type 1 and type 2 diabetic patients with microproteinuria and overt nephropathy. Comparative evaluation between a radial immunodiffusion procedure and a highly sensitive radioimmunoassay'. Together they form a unique fingerprint.

Cite this