Determination of albuminuria in type 1 and type 2 diabetic patients with microproteinuria and overt nephropathy. Comparative evaluation between a radial immunodiffusion procedure and a highly sensitive radioimmunoassay

Marisa Fioravanti; Sebastiano Bruno Solerte; Anna Linda Patti; Luisa Bacchella; Maria Grazia Zanoletti; Donatella Mancin; Nicola Schifino; Carlo Aprile; Ettore Ferrari

doi:10.1007/BF02909412

Determination of albuminuria in type 1 and type 2 diabetic patients with microproteinuria and overt nephropathy. Comparative evaluation between a radial immunodiffusion procedure and a highly sensitive radioimmunoassay

Marisa Fioravanti, Sebastiano Bruno Solerte, Anna Linda Patti, Luisa Bacchella, Maria Grazia Zanoletti, Donatella Mancin, Nicola Schifino, Carlo Aprile, Ettore Ferrari

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

We have studied the correlation between urinary albumin excretion rate evaluated by a radial immunodiffusion technique and a highly sensitive radioimmunoassay in type 1 and type 2 diabetic patients with microproteinuria and overt clinical nephropathy. Several statistically significant correlations were found between urinary albumin excretion rate measured by radial immunodiffusion and by radioimmunoassay, both in patients with microproteinuria and overt nephropathy. Moreover, statistically significant correlations between urinary albumin excretion rate, albumin clearance and total urinary protein excretion rate were observed in each of the groups studied. The radial immunodiffusion procedure can therefore be considered a useful and sensitive method for the evaluation of urinary albumin excretion rate both in diabetic patients with microproteinuria and in patients with overt clinical nephropathy.

Original language	English
Pages (from-to)	171-179
Number of pages	9
Journal	La Ricerca in Clinica e in Laboratorio
Volume	17
Issue number	2
DOIs	https://doi.org/10.1007/BF02909412
Publication status	Published - Apr 1987

Keywords

Albuminuria
Insulin-dependent diabetes mellitus
Microproteinuria
Nephropathy
Non-insulindependent diabetes mellitus

ASJC Scopus subject areas

Clinical Biochemistry

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Fioravanti, M., Solerte, S. B., Patti, A. L., Bacchella, L., Zanoletti, M. G., Mancin, D., Schifino, N., Aprile, C., & Ferrari, E. (1987). Determination of albuminuria in type 1 and type 2 diabetic patients with microproteinuria and overt nephropathy. Comparative evaluation between a radial immunodiffusion procedure and a highly sensitive radioimmunoassay. La Ricerca in Clinica e in Laboratorio, 17(2), 171-179. https://doi.org/10.1007/BF02909412

Determination of albuminuria in type 1 and type 2 diabetic patients with microproteinuria and overt nephropathy. Comparative evaluation between a radial immunodiffusion procedure and a highly sensitive radioimmunoassay. / Fioravanti, Marisa; Solerte, Sebastiano Bruno; Patti, Anna Linda; Bacchella, Luisa; Zanoletti, Maria Grazia; Mancin, Donatella; Schifino, Nicola; Aprile, Carlo; Ferrari, Ettore.

In: La Ricerca in Clinica e in Laboratorio, Vol. 17, No. 2, 04.1987, p. 171-179.

Research output: Contribution to journal › Article › peer-review

Fioravanti, M, Solerte, SB, Patti, AL, Bacchella, L, Zanoletti, MG, Mancin, D, Schifino, N, Aprile, C & Ferrari, E 1987, 'Determination of albuminuria in type 1 and type 2 diabetic patients with microproteinuria and overt nephropathy. Comparative evaluation between a radial immunodiffusion procedure and a highly sensitive radioimmunoassay', La Ricerca in Clinica e in Laboratorio, vol. 17, no. 2, pp. 171-179. https://doi.org/10.1007/BF02909412

Fioravanti M, Solerte SB, Patti AL, Bacchella L, Zanoletti MG, Mancin D et al. Determination of albuminuria in type 1 and type 2 diabetic patients with microproteinuria and overt nephropathy. Comparative evaluation between a radial immunodiffusion procedure and a highly sensitive radioimmunoassay. La Ricerca in Clinica e in Laboratorio. 1987 Apr;17(2):171-179. https://doi.org/10.1007/BF02909412

Fioravanti, Marisa ; Solerte, Sebastiano Bruno ; Patti, Anna Linda ; Bacchella, Luisa ; Zanoletti, Maria Grazia ; Mancin, Donatella ; Schifino, Nicola ; Aprile, Carlo ; Ferrari, Ettore. / Determination of albuminuria in type 1 and type 2 diabetic patients with microproteinuria and overt nephropathy. Comparative evaluation between a radial immunodiffusion procedure and a highly sensitive radioimmunoassay. In: La Ricerca in Clinica e in Laboratorio. 1987 ; Vol. 17, No. 2. pp. 171-179.

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abstract = "We have studied the correlation between urinary albumin excretion rate evaluated by a radial immunodiffusion technique and a highly sensitive radioimmunoassay in type 1 and type 2 diabetic patients with microproteinuria and overt clinical nephropathy. Several statistically significant correlations were found between urinary albumin excretion rate measured by radial immunodiffusion and by radioimmunoassay, both in patients with microproteinuria and overt nephropathy. Moreover, statistically significant correlations between urinary albumin excretion rate, albumin clearance and total urinary protein excretion rate were observed in each of the groups studied. The radial immunodiffusion procedure can therefore be considered a useful and sensitive method for the evaluation of urinary albumin excretion rate both in diabetic patients with microproteinuria and in patients with overt clinical nephropathy.",

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author = "Marisa Fioravanti and Solerte, {Sebastiano Bruno} and Patti, {Anna Linda} and Luisa Bacchella and Zanoletti, {Maria Grazia} and Donatella Mancin and Nicola Schifino and Carlo Aprile and Ettore Ferrari",

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AU - Solerte, Sebastiano Bruno

AU - Patti, Anna Linda

AU - Bacchella, Luisa

AU - Zanoletti, Maria Grazia

AU - Mancin, Donatella

AU - Schifino, Nicola

AU - Aprile, Carlo

AU - Ferrari, Ettore

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AB - We have studied the correlation between urinary albumin excretion rate evaluated by a radial immunodiffusion technique and a highly sensitive radioimmunoassay in type 1 and type 2 diabetic patients with microproteinuria and overt clinical nephropathy. Several statistically significant correlations were found between urinary albumin excretion rate measured by radial immunodiffusion and by radioimmunoassay, both in patients with microproteinuria and overt nephropathy. Moreover, statistically significant correlations between urinary albumin excretion rate, albumin clearance and total urinary protein excretion rate were observed in each of the groups studied. The radial immunodiffusion procedure can therefore be considered a useful and sensitive method for the evaluation of urinary albumin excretion rate both in diabetic patients with microproteinuria and in patients with overt clinical nephropathy.

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KW - Insulin-dependent diabetes mellitus

KW - Microproteinuria

KW - Nephropathy

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Determination of albuminuria in type 1 and type 2 diabetic patients with microproteinuria and overt nephropathy. Comparative evaluation between a radial immunodiffusion procedure and a highly sensitive radioimmunoassay

Abstract

Keywords

ASJC Scopus subject areas

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