Abstract
We have studied the correlation between urinary albumin excretion rate evaluated by a radial immunodiffusion technique and a highly sensitive radioimmunoassay in type 1 and type 2 diabetic patients with microproteinuria and overt clinical nephropathy. Several statistically significant correlations were found between urinary albumin excretion rate measured by radial immunodiffusion and by radioimmunoassay, both in patients with microproteinuria and overt nephropathy. Moreover, statistically significant correlations between urinary albumin excretion rate, albumin clearance and total urinary protein excretion rate were observed in each of the groups studied. The radial immunodiffusion procedure can therefore be considered a useful and sensitive method for the evaluation of urinary albumin excretion rate both in diabetic patients with microproteinuria and in patients with overt clinical nephropathy.
| Original language | English |
|---|---|
| Pages (from-to) | 171-179 |
| Number of pages | 9 |
| Journal | La Ricerca in Clinica e in Laboratorio |
| Volume | 17 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 1987 |
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Keywords
- Albuminuria
- Insulin-dependent diabetes mellitus
- Microproteinuria
- Nephropathy
- Non-insulindependent diabetes mellitus
ASJC Scopus subject areas
- Clinical Biochemistry
Cite this
Determination of albuminuria in type 1 and type 2 diabetic patients with microproteinuria and overt nephropathy. Comparative evaluation between a radial immunodiffusion procedure and a highly sensitive radioimmunoassay. / Fioravanti, Marisa; Solerte, Sebastiano Bruno; Patti, Anna Linda; Bacchella, Luisa; Zanoletti, Maria Grazia; Mancin, Donatella; Schifino, Nicola; Aprile, Carlo; Ferrari, Ettore.
In: La Ricerca in Clinica e in Laboratorio, Vol. 17, No. 2, 04.1987, p. 171-179.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Determination of albuminuria in type 1 and type 2 diabetic patients with microproteinuria and overt nephropathy. Comparative evaluation between a radial immunodiffusion procedure and a highly sensitive radioimmunoassay
AU - Fioravanti, Marisa
AU - Solerte, Sebastiano Bruno
AU - Patti, Anna Linda
AU - Bacchella, Luisa
AU - Zanoletti, Maria Grazia
AU - Mancin, Donatella
AU - Schifino, Nicola
AU - Aprile, Carlo
AU - Ferrari, Ettore
PY - 1987/4
Y1 - 1987/4
N2 - We have studied the correlation between urinary albumin excretion rate evaluated by a radial immunodiffusion technique and a highly sensitive radioimmunoassay in type 1 and type 2 diabetic patients with microproteinuria and overt clinical nephropathy. Several statistically significant correlations were found between urinary albumin excretion rate measured by radial immunodiffusion and by radioimmunoassay, both in patients with microproteinuria and overt nephropathy. Moreover, statistically significant correlations between urinary albumin excretion rate, albumin clearance and total urinary protein excretion rate were observed in each of the groups studied. The radial immunodiffusion procedure can therefore be considered a useful and sensitive method for the evaluation of urinary albumin excretion rate both in diabetic patients with microproteinuria and in patients with overt clinical nephropathy.
AB - We have studied the correlation between urinary albumin excretion rate evaluated by a radial immunodiffusion technique and a highly sensitive radioimmunoassay in type 1 and type 2 diabetic patients with microproteinuria and overt clinical nephropathy. Several statistically significant correlations were found between urinary albumin excretion rate measured by radial immunodiffusion and by radioimmunoassay, both in patients with microproteinuria and overt nephropathy. Moreover, statistically significant correlations between urinary albumin excretion rate, albumin clearance and total urinary protein excretion rate were observed in each of the groups studied. The radial immunodiffusion procedure can therefore be considered a useful and sensitive method for the evaluation of urinary albumin excretion rate both in diabetic patients with microproteinuria and in patients with overt clinical nephropathy.
KW - Albuminuria
KW - Insulin-dependent diabetes mellitus
KW - Microproteinuria
KW - Nephropathy
KW - Non-insulindependent diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=0023321318&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023321318&partnerID=8YFLogxK
U2 - 10.1007/BF02909412
DO - 10.1007/BF02909412
M3 - Article
VL - 17
SP - 171
EP - 179
JO - Ricerca in Clinica e in Laboratorio
JF - Ricerca in Clinica e in Laboratorio
SN - 0940-5437
IS - 2
ER -