Determination of glucocorticoids in UPLC-MS in environmental samples from an occupational setting

Enrico Oddone, Sara Negri, Massimo Bellinzona, Silvia Martino, Marcello Di Tuccio, Elena Grignani, Danilo Cottica, Marcello Imbriani

Research output: Contribution to journalArticle

Abstract

Occupational exposures to glucocorticoids are still a neglected issue in some work environments, including pharmaceutical plants. We developed an analytical method to quantify simultaneously 21 glucocorticoids using UPLC coupled with mass spectrometry to provide a basis to carry out environmental monitoring. Samples were taken from air, hand-washing tests, pad-tests and wipe-tests. This paper reports the contents of the analytical methodology, along with the results of this extensive environmental and personal monitoring of glucocorticoids. The method in UPLC-MS turned out to be suitable and effective for the aim of the study. Wipe-test and pad-test desorption was carried out using 50 mL syringes, a simple technique that saves time without adversely affecting analyte recovery. Results showed a widespread environmental pollution due to glucocorticoids. This is of particular concern. Evaluation of the dose absorbed by each worker and identification of a biomarker for occupational exposure will contribute to assessment and prevention of occupational exposure.

Original languageEnglish
Article number678579
JournalInternational Journal of Analytical Chemistry
Volume2015
DOIs
Publication statusPublished - 2015

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Glucocorticoids
Drug products plants
Syringes
Monitoring
Biomarkers
Washing
Mass spectrometry
Desorption
Pollution
Recovery
Air

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Determination of glucocorticoids in UPLC-MS in environmental samples from an occupational setting. / Oddone, Enrico; Negri, Sara; Bellinzona, Massimo; Martino, Silvia; Di Tuccio, Marcello; Grignani, Elena; Cottica, Danilo; Imbriani, Marcello.

In: International Journal of Analytical Chemistry, Vol. 2015, 678579, 2015.

Research output: Contribution to journalArticle

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AU - Cottica, Danilo

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