Determination of HIV-1 Co-receptor usage

Mariangela Cavarelli, Gabriella Scarlatti

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Human immunodeficiency virus type I (HIV-1) infects target cells through interaction with the CD4 molecule and chemokine receptors, mainly the β-chemokine receptor 5 (CCR5) and the α-chemokine receptor 4 (CXCR4). Viral isolates can be phenotypically classified based on the co-receptor they utilize to infect target cells. In this chapter, methods to determine the co-receptor usage of HIV-1 variants are described.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages197-206
Number of pages10
Volume1087
ISBN (Print)9781627036696
DOIs
Publication statusPublished - 2014

Publication series

NameMethods in Molecular Biology
Volume1087
ISSN (Print)10643745

Keywords

  • CCR5/CXCR4 chimeric receptors
  • Co-receptor
  • GHOST(3) cell line
  • HIV-1
  • U87.CD4 cell line

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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