TY - CHAP
T1 - Determination of HIV-1 Co-receptor usage
AU - Cavarelli, Mariangela
AU - Scarlatti, Gabriella
PY - 2014
Y1 - 2014
N2 - Human immunodeficiency virus type I (HIV-1) infects target cells through interaction with the CD4 molecule and chemokine receptors, mainly the β-chemokine receptor 5 (CCR5) and the α-chemokine receptor 4 (CXCR4). Viral isolates can be phenotypically classified based on the co-receptor they utilize to infect target cells. In this chapter, methods to determine the co-receptor usage of HIV-1 variants are described.
AB - Human immunodeficiency virus type I (HIV-1) infects target cells through interaction with the CD4 molecule and chemokine receptors, mainly the β-chemokine receptor 5 (CCR5) and the α-chemokine receptor 4 (CXCR4). Viral isolates can be phenotypically classified based on the co-receptor they utilize to infect target cells. In this chapter, methods to determine the co-receptor usage of HIV-1 variants are described.
KW - CCR5/CXCR4 chimeric receptors
KW - Co-receptor
KW - GHOST(3) cell line
KW - HIV-1
KW - U87.CD4 cell line
UR - http://www.scopus.com/inward/record.url?scp=84934435320&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84934435320&partnerID=8YFLogxK
U2 - 10.1007/978-1-62703-670-2_16
DO - 10.1007/978-1-62703-670-2_16
M3 - Chapter
AN - SCOPUS:84934435320
SN - 9781627036696
VL - 1087
T3 - Methods in Molecular Biology
SP - 197
EP - 206
BT - Methods in Molecular Biology
PB - Humana Press Inc.
ER -