Determination of HIV-1 Co-receptor usage

Mariangela Cavarelli, Gabriella Scarlatti

Research output: Contribution to journalArticle

Abstract

Human immunodeficiency virus type I (HIV-1) infects target cells through interaction with the CD4 molecule and chemokine receptors, mainly the β-chemokine receptor 5 (CCR5) and the α-chemokine receptor 4 (CXCR4). Viral isolates can be phenotypically classified based on the co-receptor they utilize to infect target cells. In this chapter, methods to determine the co-receptor usage of HIV-1 variants are described.

Original languageEnglish
Pages (from-to)197-206
Number of pages10
JournalMethods in molecular biology (Clifton, N.J.)
Volume1087
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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