Ricerca di HIV-RNA mediante ibridizzazione in situ su tessuto miocardico. Ruolo dell'HIV nelle miocardiopatie in corso di AIDS.

Translated title of the contribution: Determination of HIV-RNA using in situ hybridization on myocardial tissue. Role of HIV in cardiomyopathy in AIDS

P. Mencarini, E. Tamburrini, A. Antinori, G. Zannoni, A. De Luca, A. Capelli, L. Ortona

Research output: Contribution to journalArticle

Abstract

Aim of this study was to evaluate the presence of HIV-1 and CMV genomic sequences in myocardial tissue from autopsy of AIDS patients by in situ hybridization technique and to make a correlation with clinical and/or pathological signs of myocarditis. Seven patients out of 12 (58.3%) were positive for HIV-1 (6/7 patients with pathological signs of myocarditis and 1/5 without pathological abnormalities; p = 0.029). In situ hybridization for CMV was positive in 5/12 patients (41.7%) (3 with myocarditis and 2 without myocarditis); three clinically symptomatic cases were contemporary positive for HIV-1 and CMV. Our results seem to confirm emerging data about the presence of HIV-1 in myocardial tissue and about the possible role of HIV-1 in determining cardiac pathologies. Furthermore we suggest the hypothesis of an interaction of HIV-1 and CMV in latest of HIV infection.

Translated title of the contributionDetermination of HIV-RNA using in situ hybridization on myocardial tissue. Role of HIV in cardiomyopathy in AIDS
Original languageItalian
Pages (from-to)457-465
Number of pages9
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume70
Issue number1-2
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Immunology

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