Determination of ifosfamide by HPLC using on-line sample preparation

Carola Zolezzi, S. Ferrari, G. Bacci, M. C. Fasano, G. Sormani, A. Pizzoferrato

Research output: Contribution to journalArticlepeer-review


The Authors have developed a novel and easily applicable HPLC method for ifosfamide (IF) determination. This method involves on-line sample processing and its solid-phase extraction by means of an automatic preparator integrated with the chromatographic system. The calibration graph of the method is linear in the concentration range 6-200 μg/ml; minimum detectable concentration is 6 μg/ml. This highly accurate and easily reproducible method was used by the Authors in the treatment of osteosarcoma with slow infusion of ifosfamide.

Original languageEnglish
Pages (from-to)69-73
Number of pages5
JournalJournal of Chemotherapy
Issue number1
Publication statusPublished - 1999


  • HPLC determination
  • Ifosfamide
  • Sarcoma chemotherapy

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)


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