Abstract
The Authors have developed a novel and easily applicable HPLC method for ifosfamide (IF) determination. This method involves on-line sample processing and its solid-phase extraction by means of an automatic preparator integrated with the chromatographic system. The calibration graph of the method is linear in the concentration range 6-200 μg/ml; minimum detectable concentration is 6 μg/ml. This highly accurate and easily reproducible method was used by the Authors in the treatment of osteosarcoma with slow infusion of ifosfamide.
| Original language | English |
|---|---|
| Pages (from-to) | 69-73 |
| Number of pages | 5 |
| Journal | Journal of Chemotherapy |
| Volume | 11 |
| Issue number | 1 |
| Publication status | Published - 1999 |
Keywords
- HPLC determination
- Ifosfamide
- Sarcoma chemotherapy
ASJC Scopus subject areas
- Microbiology (medical)
- Pharmacology (medical)