Abstract
In this paper we show the possibility to apply the analysis of the hypervariable minisatellites present in the human genome to the diagnosis of paternity. We take advantage of the recent discovery by Jeffreys and Coll. at the University of Leicester (U.K.) of middle repetitive DNA segments (minisatellites) which show an extreme degree of polymorphism in humans. Making use of particular probes for these regions of the human genome it is possible to establish individual DNA fingerprints of more precise value than usual fingerprints. The polymorphic DNA minisatellites are transmitted stably as mendelian characters through generations and it is possible to demonstrate that the number and length of minisatellites in each individual is inherited in the proportion of 50% from each parent. Here we refer to the use of this new DNA recombinant technology to exclude or to ascertain (prove) with certainty the paternity in a legal contest.
| Original language | English |
|---|---|
| Title of host publication | Rivista Italiana di Medicina Legale |
| Pages | 234-247 |
| Number of pages | 14 |
| Volume | 10 |
| Edition | 1 |
| Publication status | Published - 1988 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Determination of individual genetic pattern by analysis of hypervariable minisatellites as a new method for establishment of paternity. General considerations and descriptions of a disputed case. / Romano, C.; De Robertis, M.; Esposito, M.; Ciliberto, G.; Pistone, A.; Cortese, R.
Rivista Italiana di Medicina Legale. Vol. 10 1. ed. 1988. p. 234-247.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Determination of individual genetic pattern by analysis of hypervariable minisatellites as a new method for establishment of paternity. General considerations and descriptions of a disputed case
AU - Romano, C.
AU - De Robertis, M.
AU - Esposito, M.
AU - Ciliberto, G.
AU - Pistone, A.
AU - Cortese, R.
PY - 1988
Y1 - 1988
N2 - In this paper we show the possibility to apply the analysis of the hypervariable minisatellites present in the human genome to the diagnosis of paternity. We take advantage of the recent discovery by Jeffreys and Coll. at the University of Leicester (U.K.) of middle repetitive DNA segments (minisatellites) which show an extreme degree of polymorphism in humans. Making use of particular probes for these regions of the human genome it is possible to establish individual DNA fingerprints of more precise value than usual fingerprints. The polymorphic DNA minisatellites are transmitted stably as mendelian characters through generations and it is possible to demonstrate that the number and length of minisatellites in each individual is inherited in the proportion of 50% from each parent. Here we refer to the use of this new DNA recombinant technology to exclude or to ascertain (prove) with certainty the paternity in a legal contest.
AB - In this paper we show the possibility to apply the analysis of the hypervariable minisatellites present in the human genome to the diagnosis of paternity. We take advantage of the recent discovery by Jeffreys and Coll. at the University of Leicester (U.K.) of middle repetitive DNA segments (minisatellites) which show an extreme degree of polymorphism in humans. Making use of particular probes for these regions of the human genome it is possible to establish individual DNA fingerprints of more precise value than usual fingerprints. The polymorphic DNA minisatellites are transmitted stably as mendelian characters through generations and it is possible to demonstrate that the number and length of minisatellites in each individual is inherited in the proportion of 50% from each parent. Here we refer to the use of this new DNA recombinant technology to exclude or to ascertain (prove) with certainty the paternity in a legal contest.
UR - http://www.scopus.com/inward/record.url?scp=0023768422&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023768422&partnerID=8YFLogxK
M3 - Chapter
AN - SCOPUS:0023768422
VL - 10
SP - 234
EP - 247
BT - Rivista Italiana di Medicina Legale
ER -