Determination of kFLC and K index in cerebrospinal fluid: A valid alternative to assessintrathecal immunoglobulin synthesis

Fabio Duranti, Massimo Pieri, Diego Centonze, Fabio Buttari, Sergio Bernardini, Mariarita Dessi

Research output: Contribution to journalArticle


Intrathecal immunoglobulin synthesis is observed in several disorders of the central nervous system, but its detection by current laboratory tests is relatively insensitive and operator depending. We assessed the diagnostic accuracy of a nephelometric assay for k free light chain determination in cerebrospinal fluid and serum. The patients were grouped according to clinical and laboratory criteria. ROC curves for all methods were performed to find the best cut-off value. kFLC Index seems to be more accurate than other parameters. Our data indicate that nephelometric assay for kFLCs in CSF reliably detect intrathecal immunoglobulin synthesis and discriminate multiple sclerosis patients.

Original languageEnglish
Pages (from-to)116-120
Number of pages5
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - Oct 15 2013



  • CSF
  • KFLC Index
  • KFLCs
  • Multiple sclerosis
  • Nephelometry
  • OCBs

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology
  • Medicine(all)

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