Determination of medium chain fatty acids in serum

Carlo Dionisi Vici, Claude Bachmann, Marianne Gradwoht, Jean Pierre Colombo

Research output: Contribution to journalArticlepeer-review


The determination of medium chain fatty acids in serum is a useful approach to the diagnosis of medium chain acyl-CoA dehydrogenase deficiency, an increasingly recognized cause of Reye-like syndrome in infants. A reliable and practical method requiring 0.5 ml of serum is presented by which results are obtained within 2.5 h. The preparation of the samples is done by solid phase extraction on reverse phase cartridges, the separation and quantitation by gas chromatography. Reference values for children (n = 24) and adults (n = 40) are given for octanoic, decanoic and dodecanoic acids.

Original languageEnglish
Pages (from-to)233-238
Number of pages6
JournalClinica Chimica Acta
Issue number2-3
Publication statusPublished - Mar 15 1988


  • acyl-CoA dehydrogenase deficiency
  • Decanoic acid
  • Dodecanoic acid
  • Medium chain fatty acid
  • Octanoic acid

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry


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