Determinazione della Mesotelina nel versamento pleurico: Contributo alla citologia nella diagnosi del Mesotelioma pleurico maligno

Enrico Battolla; Pier Aldo Canessa; Paola Ferro; Antonella Vigani; Vincenzo Fontana; Maria Cristiana Franceschini; Carmen Manta; Paolo Dessanti; Gianluca Masini; Rita Lanzoni; Fabrizio Via; Rosamaria Cocilovo; Franco Fedeli; Maria Pia Pistillo; Silvio Roncella

doi:10.1007/s13631-012-0047-y

Determinazione della Mesotelina nel versamento pleurico: Contributo alla citologia nella diagnosi del Mesotelioma pleurico maligno

Translated title of the contribution: Determination of mesothelin in pleural effusions: Contribution to cytology for diagnosis of malignant pleural mesotelioma

Enrico Battolla, Pier Aldo Canessa, Paola Ferro, Antonella Vigani, Vincenzo Fontana, Maria Cristiana Franceschini, Carmen Manta, Paolo Dessanti, Gianluca Masini, Rita Lanzoni, Fabrizio Via, Rosamaria Cocilovo, Franco Fedeli, Maria Pia Pistillo, Silvio Roncella

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article

Abstract

Background. Malignant pleural mesothelioma (MPM) is an aggressive tumour usually associated with the presence of pleural effusion (PE). Differential diagnosis of the PE can be difficult because cytological analysis shows low sensitivity and specificity. Measurement of solubile mesothelin peptides (MS) has been reported to provide a complementary tool to aid in the diagnosis of MPM. The current study was undertaken to assess whether the levels of MS in PE may provide an additional diagnostic value to cytology and clinical practice. Methods. MS was assessed by means of the MesoMarkTM ELISA kit on a fraction of PE extracted by thoracentesis. Cytology was evaluated on fixed smears stained by Papanicolaou's method. Results. We evaluated MS in 52 MPM-PE and 223 PE of other origin. The geometric mean of MS levels in PE was significantly higher in MPM-PE (19.0 nmol/L) than in total other PE (3.5 nmol/L). The cut-off level was 9.30 nmol/L with an AUC of 82.0 (P-value

Original language	Italian
Pages (from-to)	94-100
Number of pages	7
Journal	Rivista Italiana della Medicina di Laboratorio
Volume	8
Issue number	2
DOIs	https://doi.org/10.1007/s13631-012-0047-y
Publication status	Published - Jun 2012

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ASJC Scopus subject areas

Biochemistry, medical
Medical Laboratory Technology

Cite this

Battolla, E., Canessa, P. A., Ferro, P., Vigani, A., Fontana, V., Franceschini, M. C., Manta, C., Dessanti, P., Masini, G., Lanzoni, R., Via, F., Cocilovo, R., Fedeli, F., Pistillo, M. P., & Roncella, S. (2012). Determinazione della Mesotelina nel versamento pleurico: Contributo alla citologia nella diagnosi del Mesotelioma pleurico maligno. Rivista Italiana della Medicina di Laboratorio, 8(2), 94-100. https://doi.org/10.1007/s13631-012-0047-y

Determinazione della Mesotelina nel versamento pleurico : Contributo alla citologia nella diagnosi del Mesotelioma pleurico maligno. / Battolla, Enrico; Canessa, Pier Aldo; Ferro, Paola; Vigani, Antonella; Fontana, Vincenzo; Franceschini, Maria Cristiana; Manta, Carmen; Dessanti, Paolo; Masini, Gianluca; Lanzoni, Rita; Via, Fabrizio; Cocilovo, Rosamaria; Fedeli, Franco; Pistillo, Maria Pia; Roncella, Silvio.

In: Rivista Italiana della Medicina di Laboratorio, Vol. 8, No. 2, 06.2012, p. 94-100.

Research output: Contribution to journal › Article

Battolla, E, Canessa, PA, Ferro, P, Vigani, A, Fontana, V, Franceschini, MC, Manta, C, Dessanti, P, Masini, G, Lanzoni, R, Via, F, Cocilovo, R, Fedeli, F, Pistillo, MP & Roncella, S 2012, 'Determinazione della Mesotelina nel versamento pleurico: Contributo alla citologia nella diagnosi del Mesotelioma pleurico maligno', Rivista Italiana della Medicina di Laboratorio, vol. 8, no. 2, pp. 94-100. https://doi.org/10.1007/s13631-012-0047-y

Battolla, Enrico ; Canessa, Pier Aldo ; Ferro, Paola ; Vigani, Antonella ; Fontana, Vincenzo ; Franceschini, Maria Cristiana ; Manta, Carmen ; Dessanti, Paolo ; Masini, Gianluca ; Lanzoni, Rita ; Via, Fabrizio ; Cocilovo, Rosamaria ; Fedeli, Franco ; Pistillo, Maria Pia ; Roncella, Silvio. / Determinazione della Mesotelina nel versamento pleurico : Contributo alla citologia nella diagnosi del Mesotelioma pleurico maligno. In: Rivista Italiana della Medicina di Laboratorio. 2012 ; Vol. 8, No. 2. pp. 94-100.

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abstract = "Background. Malignant pleural mesothelioma (MPM) is an aggressive tumour usually associated with the presence of pleural effusion (PE). Differential diagnosis of the PE can be difficult because cytological analysis shows low sensitivity and specificity. Measurement of solubile mesothelin peptides (MS) has been reported to provide a complementary tool to aid in the diagnosis of MPM. The current study was undertaken to assess whether the levels of MS in PE may provide an additional diagnostic value to cytology and clinical practice. Methods. MS was assessed by means of the MesoMarkTM ELISA kit on a fraction of PE extracted by thoracentesis. Cytology was evaluated on fixed smears stained by Papanicolaou's method. Results. We evaluated MS in 52 MPM-PE and 223 PE of other origin. The geometric mean of MS levels in PE was significantly higher in MPM-PE (19.0 nmol/L) than in total other PE (3.5 nmol/L). The cut-off level was 9.30 nmol/L with an AUC of 82.0 (P-value ",

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AU - Canessa, Pier Aldo

AU - Ferro, Paola

AU - Vigani, Antonella

AU - Fontana, Vincenzo

AU - Franceschini, Maria Cristiana

AU - Manta, Carmen

AU - Dessanti, Paolo

AU - Masini, Gianluca

AU - Lanzoni, Rita

AU - Via, Fabrizio

AU - Cocilovo, Rosamaria

AU - Fedeli, Franco

AU - Pistillo, Maria Pia

AU - Roncella, Silvio

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N2 - Background. Malignant pleural mesothelioma (MPM) is an aggressive tumour usually associated with the presence of pleural effusion (PE). Differential diagnosis of the PE can be difficult because cytological analysis shows low sensitivity and specificity. Measurement of solubile mesothelin peptides (MS) has been reported to provide a complementary tool to aid in the diagnosis of MPM. The current study was undertaken to assess whether the levels of MS in PE may provide an additional diagnostic value to cytology and clinical practice. Methods. MS was assessed by means of the MesoMarkTM ELISA kit on a fraction of PE extracted by thoracentesis. Cytology was evaluated on fixed smears stained by Papanicolaou's method. Results. We evaluated MS in 52 MPM-PE and 223 PE of other origin. The geometric mean of MS levels in PE was significantly higher in MPM-PE (19.0 nmol/L) than in total other PE (3.5 nmol/L). The cut-off level was 9.30 nmol/L with an AUC of 82.0 (P-value

AB - Background. Malignant pleural mesothelioma (MPM) is an aggressive tumour usually associated with the presence of pleural effusion (PE). Differential diagnosis of the PE can be difficult because cytological analysis shows low sensitivity and specificity. Measurement of solubile mesothelin peptides (MS) has been reported to provide a complementary tool to aid in the diagnosis of MPM. The current study was undertaken to assess whether the levels of MS in PE may provide an additional diagnostic value to cytology and clinical practice. Methods. MS was assessed by means of the MesoMarkTM ELISA kit on a fraction of PE extracted by thoracentesis. Cytology was evaluated on fixed smears stained by Papanicolaou's method. Results. We evaluated MS in 52 MPM-PE and 223 PE of other origin. The geometric mean of MS levels in PE was significantly higher in MPM-PE (19.0 nmol/L) than in total other PE (3.5 nmol/L). The cut-off level was 9.30 nmol/L with an AUC of 82.0 (P-value

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