Determination of neurochemicals in biological fluids by using an automated high-performance liquid chromatographic system with a coulometric array detector

Vittoria Rizzo, Gianvico Melzi D'eril, Guido Achilli, Gian Piero Cellerino

Research output: Contribution to journalArticle

Abstract

The chromatographic separation of 33 neurochemicals was achieved by using a combined gradient of organic modifier, pH and counter-ion. A secondary separation of unresolved analytes was obtained by using electrochemical detection with a coulometric array of sixteen electrodes. The stability of the analytes was studied and data on analytical performance are reported in addition to a list of neurochemicals detected in a normal plasma sample.

Original languageEnglish
Pages (from-to)229-236
Number of pages8
JournalJournal of Chromatography A
Volume536
Issue numberC
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry
  • Molecular Medicine

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