Determination of papaverine in human blood by electron capture-gas liquid chromatography

E. Zuccato, F. Marcucci, E. Mussini

Research output: Contribution to journalArticle

Abstract

A highly sensitive and specific assay for papaverine in whole human blood at concentrations as low as 10 mg/ml has been developed, using electron capture-gas liquid chromatography (EC-GLC). Blood concentrations of papaverine in humans were measured after oral administration of 4 mg/kg of papaverine. The new extractive technique uses Amberlite XAD-7, nonionic, which permits rapid and accurate papaverine analysis with the advantage of economy. The identity of the GLC peak was checked by GLC coupled with mass spectrometry (MS).

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalJournal of Pharmacological Methods
Volume1
Issue number1
DOIs
Publication statusPublished - 1978

    Fingerprint

Keywords

  • EC/GLC assay
  • Human blood
  • Papaverine

ASJC Scopus subject areas

  • Pharmacology

Cite this