Abstract
A method was developed for the determination of rare earth elements (REEs) in urine with electrothermal vaporization inductively coupled plasma mass spectrometry (ETV-ICPMS). The undiluted sample was directly injected into the graphite tube and trifluoromethane (Freon-23) was used as chemical modifier in order to reduce the vaporization temperature and the memory effect of most of the lanthanides. The detection limits were in the range 1-10 ng/L with relative standard deviation of 3-5% at concentration levels of 1 μg/L, and less than 10-15% at 100 ng/L. Two different procedures, external calibration and a standard additions method, were evaluated to measure the concentration levels of lanthanides in the urine samples and the second procedure was considered to be the best choice for calibration in this work. The level of REEs in urine of 50 healthy volunteers was in the range 5-20 ng/L, above the detection limit of ETV-ICPMS.
| Original language | English |
|---|---|
| Pages (from-to) | 579-584 |
| Number of pages | 6 |
| Journal | Rapid Communications in Mass Spectrometry |
| Volume | 16 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2002 |
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ASJC Scopus subject areas
- Analytical Chemistry
- Spectroscopy
Cite this
Determination of rare earth elements in urine by electrothermal vaporization inductively coupled plasma mass spectrometry. / Bettinelli, Maurizio; Spezia, Sandro; Terni, Cesarina; Ronchi, Anna; Balducci, Claudio; Minoia, Claudio.
In: Rapid Communications in Mass Spectrometry, Vol. 16, No. 6, 2002, p. 579-584.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Determination of rare earth elements in urine by electrothermal vaporization inductively coupled plasma mass spectrometry
AU - Bettinelli, Maurizio
AU - Spezia, Sandro
AU - Terni, Cesarina
AU - Ronchi, Anna
AU - Balducci, Claudio
AU - Minoia, Claudio
PY - 2002
Y1 - 2002
N2 - A method was developed for the determination of rare earth elements (REEs) in urine with electrothermal vaporization inductively coupled plasma mass spectrometry (ETV-ICPMS). The undiluted sample was directly injected into the graphite tube and trifluoromethane (Freon-23) was used as chemical modifier in order to reduce the vaporization temperature and the memory effect of most of the lanthanides. The detection limits were in the range 1-10 ng/L with relative standard deviation of 3-5% at concentration levels of 1 μg/L, and less than 10-15% at 100 ng/L. Two different procedures, external calibration and a standard additions method, were evaluated to measure the concentration levels of lanthanides in the urine samples and the second procedure was considered to be the best choice for calibration in this work. The level of REEs in urine of 50 healthy volunteers was in the range 5-20 ng/L, above the detection limit of ETV-ICPMS.
AB - A method was developed for the determination of rare earth elements (REEs) in urine with electrothermal vaporization inductively coupled plasma mass spectrometry (ETV-ICPMS). The undiluted sample was directly injected into the graphite tube and trifluoromethane (Freon-23) was used as chemical modifier in order to reduce the vaporization temperature and the memory effect of most of the lanthanides. The detection limits were in the range 1-10 ng/L with relative standard deviation of 3-5% at concentration levels of 1 μg/L, and less than 10-15% at 100 ng/L. Two different procedures, external calibration and a standard additions method, were evaluated to measure the concentration levels of lanthanides in the urine samples and the second procedure was considered to be the best choice for calibration in this work. The level of REEs in urine of 50 healthy volunteers was in the range 5-20 ng/L, above the detection limit of ETV-ICPMS.
UR - http://www.scopus.com/inward/record.url?scp=0036009112&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036009112&partnerID=8YFLogxK
U2 - 10.1002/rcm.609
DO - 10.1002/rcm.609
M3 - Article
C2 - 11870895
AN - SCOPUS:0036009112
VL - 16
SP - 579
EP - 584
JO - Rapid Communications in Mass Spectrometry
JF - Rapid Communications in Mass Spectrometry
SN - 0951-4198
IS - 6
ER -