Determination of S-phenylmercapturic acid in urine as an indicator of exposure to benzene

Sergio Ghittori; Marcello Imbriani; Luciano Maestri; Emanuele Capodaglio; Alessandro Cavalleri

doi:10.1016/S0378-4274(99)00106-X

Determination of S-phenylmercapturic acid in urine as an indicator of exposure to benzene

Sergio Ghittori, Marcello Imbriani, Luciano Maestri, Emanuele Capodaglio, Alessandro Cavalleri

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

S-phenylmercapturic acid (S-PMA) was measured in urine from 145 subjects exposed to low benzene concentrations in the air (C(I), benzene). The 8-h, time-weighted exposure intensity of individual workers was monitored by means of charcoal tubes and subsequent gas-chromatographic analysis after desorption with CS₂. S-PMA excretion level in urine was determined by high- performance liquid chromatography with fluorescence detection. The following linear correlation was found between S-PMA concentrations in urine and benzene concentrations in the breathing zone: log(S-PMA, μg/g creatinine)=0.712 log (C(I)-benzene, ppm) + 1.644 (n=145, r=0.74, P

Original language	English
Pages (from-to)	329-334
Number of pages	6
Journal	Toxicology Letters
Volume	108
Issue number	2-3
DOIs	https://doi.org/10.1016/S0378-4274(99)00106-X
Publication status	Published - Sep 5 1999

Keywords

Benzene
S-Phenylmercapturic acid
Urinalysis

ASJC Scopus subject areas

Toxicology

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10.1016/S0378-4274(99)00106-X

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title = "Determination of S-phenylmercapturic acid in urine as an indicator of exposure to benzene",

abstract = "S-phenylmercapturic acid (S-PMA) was measured in urine from 145 subjects exposed to low benzene concentrations in the air (C(I), benzene). The 8-h, time-weighted exposure intensity of individual workers was monitored by means of charcoal tubes and subsequent gas-chromatographic analysis after desorption with CS2. S-PMA excretion level in urine was determined by high- performance liquid chromatography with fluorescence detection. The following linear correlation was found between S-PMA concentrations in urine and benzene concentrations in the breathing zone: log(S-PMA, μg/g creatinine)=0.712 log (C(I)-benzene, ppm) + 1.644 (n=145, r=0.74, P",

keywords = "Benzene, S-Phenylmercapturic acid, Urinalysis",

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T1 - Determination of S-phenylmercapturic acid in urine as an indicator of exposure to benzene

AU - Ghittori, Sergio

AU - Imbriani, Marcello

AU - Maestri, Luciano

AU - Capodaglio, Emanuele

AU - Cavalleri, Alessandro

PY - 1999/9/5

Y1 - 1999/9/5

N2 - S-phenylmercapturic acid (S-PMA) was measured in urine from 145 subjects exposed to low benzene concentrations in the air (C(I), benzene). The 8-h, time-weighted exposure intensity of individual workers was monitored by means of charcoal tubes and subsequent gas-chromatographic analysis after desorption with CS2. S-PMA excretion level in urine was determined by high- performance liquid chromatography with fluorescence detection. The following linear correlation was found between S-PMA concentrations in urine and benzene concentrations in the breathing zone: log(S-PMA, μg/g creatinine)=0.712 log (C(I)-benzene, ppm) + 1.644 (n=145, r=0.74, P

AB - S-phenylmercapturic acid (S-PMA) was measured in urine from 145 subjects exposed to low benzene concentrations in the air (C(I), benzene). The 8-h, time-weighted exposure intensity of individual workers was monitored by means of charcoal tubes and subsequent gas-chromatographic analysis after desorption with CS2. S-PMA excretion level in urine was determined by high- performance liquid chromatography with fluorescence detection. The following linear correlation was found between S-PMA concentrations in urine and benzene concentrations in the breathing zone: log(S-PMA, μg/g creatinine)=0.712 log (C(I)-benzene, ppm) + 1.644 (n=145, r=0.74, P

KW - Benzene

KW - S-Phenylmercapturic acid

KW - Urinalysis

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