Determination of S-phenylmercapturic acid in urine as an indicator of exposure to benzene

Sergio Ghittori, Marcello Imbriani, Luciano Maestri, Emanuele Capodaglio, Alessandro Cavalleri

Research output: Contribution to journalArticlepeer-review

Abstract

S-phenylmercapturic acid (S-PMA) was measured in urine from 145 subjects exposed to low benzene concentrations in the air (C(I), benzene). The 8-h, time-weighted exposure intensity of individual workers was monitored by means of charcoal tubes and subsequent gas-chromatographic analysis after desorption with CS2. S-PMA excretion level in urine was determined by high- performance liquid chromatography with fluorescence detection. The following linear correlation was found between S-PMA concentrations in urine and benzene concentrations in the breathing zone: log(S-PMA, μg/g creatinine)=0.712 log (C(I)-benzene, ppm) + 1.644 (n=145, r=0.74, P

Original languageEnglish
Pages (from-to)329-334
Number of pages6
JournalToxicology Letters
Volume108
Issue number2-3
DOIs
Publication statusPublished - Sep 5 1999

Keywords

  • Benzene
  • S-Phenylmercapturic acid
  • Urinalysis

ASJC Scopus subject areas

  • Toxicology

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