Determination of S-phenylmercapturic acid in urine as an indicator of exposure to benzene

Sergio Ghittori, Marcello Imbriani, Luciano Maestri, Emanuele Capodaglio, Alessandro Cavalleri

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

S-phenylmercapturic acid (S-PMA) was measured in urine from 145 subjects exposed to low benzene concentrations in the air (C(I), benzene). The 8-h, time-weighted exposure intensity of individual workers was monitored by means of charcoal tubes and subsequent gas-chromatographic analysis after desorption with CS2. S-PMA excretion level in urine was determined by high- performance liquid chromatography with fluorescence detection. The following linear correlation was found between S-PMA concentrations in urine and benzene concentrations in the breathing zone: log(S-PMA, μg/g creatinine)=0.712 log (C(I)-benzene, ppm) + 1.644 (n=145, r=0.74, P

Original languageEnglish
Pages (from-to)329-334
Number of pages6
JournalToxicology Letters
Volume108
Issue number2-3
DOIs
Publication statusPublished - Sep 5 1999

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Benzene
Urine
Charcoal
High performance liquid chromatography
Gas chromatography
Gas Chromatography
Desorption
Creatinine
Respiration
Fluorescence
Air
High Pressure Liquid Chromatography
S-phenyl-N-acetylcysteine

Keywords

  • Benzene
  • S-Phenylmercapturic acid
  • Urinalysis

ASJC Scopus subject areas

  • Toxicology

Cite this

Determination of S-phenylmercapturic acid in urine as an indicator of exposure to benzene. / Ghittori, Sergio; Imbriani, Marcello; Maestri, Luciano; Capodaglio, Emanuele; Cavalleri, Alessandro.

In: Toxicology Letters, Vol. 108, No. 2-3, 05.09.1999, p. 329-334.

Research output: Contribution to journalArticle

Ghittori, Sergio ; Imbriani, Marcello ; Maestri, Luciano ; Capodaglio, Emanuele ; Cavalleri, Alessandro. / Determination of S-phenylmercapturic acid in urine as an indicator of exposure to benzene. In: Toxicology Letters. 1999 ; Vol. 108, No. 2-3. pp. 329-334.
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