Determination of tamoxifen and its metabolites in the endometrial tissue of long-term treated women

G. Giorda, L. Franceschi, D. Crivellari, M. D. Magri, A. Veronesi, C. Scarabelli, M. Furlanut

Research output: Contribution to journalArticlepeer-review

Abstract

Concentrations of tamoxifen and its metabolites were analysed in the endometrium of 23 post-menopausal asymptomatic breast cancer patients who were on chronic tamoxifen therapy. Small endometrial samples were collected during diagnostic hysteroscopy. Analysis of both serum and tissue for these compounds was performed by mass spectrometry. Tamoxifen and its metabolites were far more concentrated in the endometrium than in serum; tamoxifen was also significantly more concentrated in endometrium with hyperplastic changes than in atrophic endometrium. Endometrial polyps of an additional 9 women showed a trend to a lesser concentration of compounds. Increased concentration of tamoxifen compounds could possibly be explained by the avidity of these compounds for oestrogen receptors (ER). (C) 2000 Elsevier Science Ltd.

Original languageEnglish
JournalEuropean Journal of Cancer
Volume36
Issue numberSUPPL. 4
Publication statusPublished - 2000

Keywords

  • Endometrium
  • Tamoxifen
  • Tissue distribution

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Fingerprint

Dive into the research topics of 'Determination of tamoxifen and its metabolites in the endometrial tissue of long-term treated women'. Together they form a unique fingerprint.

Cite this