Determination of whether screening tests for chronic atrophic gastritis really has a positive predictive value

Flaviano Di Paola, Valentina D'Angelo, Fabiana Tatangelo, Vittoria Barchiesi, Marianna Rizzo, Monica Cantile, Gerardo Botti, Ernesta Cavalcanti

Research output: Contribution to journalArticle

Abstract

Intestinal-type gastric adenocarcinomas are preceded by precancerous lesions, which begin with chronic atrophic gastritis. Over the last few years, multiple serological screening techniques have been performed and commercialized for the diagnosis of chronic atrophic gastritis. In the present study, 123 patients were recruited at the International Cancer Institute 'G. Pascale' Foundation (Naples, Italy) to test commercial kits for the serological determination of chronic atrophic gastritis, supported by histological analysis, according to the International Group of Gastroenterologists 'Operative Link for Gastritis Assessment Staging System'. The results revealed a significant discrepancy between serological screening and histological evaluation in 10.6% of patients, which highlighted the dubious positive predictive value of commercial serological screening kits.

Original languageEnglish
Pages (from-to)3521-3524
Number of pages4
JournalMolecular Medicine Reports
Volume12
Issue number3
DOIs
Publication statusPublished - Sep 1 2015

Keywords

  • Chronic atrophic gastritis
  • Operative Link for Gastritis Assessment Staging System
  • Serological test

ASJC Scopus subject areas

  • Biochemistry
  • Cancer Research
  • Genetics
  • Molecular Biology
  • Molecular Medicine
  • Oncology

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