TY - JOUR
T1 - Determination of whether screening tests for chronic atrophic gastritis really has a positive predictive value
AU - Di Paola, Flaviano
AU - D'Angelo, Valentina
AU - Tatangelo, Fabiana
AU - Barchiesi, Vittoria
AU - Rizzo, Marianna
AU - Cantile, Monica
AU - Botti, Gerardo
AU - Cavalcanti, Ernesta
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Intestinal-type gastric adenocarcinomas are preceded by precancerous lesions, which begin with chronic atrophic gastritis. Over the last few years, multiple serological screening techniques have been performed and commercialized for the diagnosis of chronic atrophic gastritis. In the present study, 123 patients were recruited at the International Cancer Institute 'G. Pascale' Foundation (Naples, Italy) to test commercial kits for the serological determination of chronic atrophic gastritis, supported by histological analysis, according to the International Group of Gastroenterologists 'Operative Link for Gastritis Assessment Staging System'. The results revealed a significant discrepancy between serological screening and histological evaluation in 10.6% of patients, which highlighted the dubious positive predictive value of commercial serological screening kits.
AB - Intestinal-type gastric adenocarcinomas are preceded by precancerous lesions, which begin with chronic atrophic gastritis. Over the last few years, multiple serological screening techniques have been performed and commercialized for the diagnosis of chronic atrophic gastritis. In the present study, 123 patients were recruited at the International Cancer Institute 'G. Pascale' Foundation (Naples, Italy) to test commercial kits for the serological determination of chronic atrophic gastritis, supported by histological analysis, according to the International Group of Gastroenterologists 'Operative Link for Gastritis Assessment Staging System'. The results revealed a significant discrepancy between serological screening and histological evaluation in 10.6% of patients, which highlighted the dubious positive predictive value of commercial serological screening kits.
KW - Chronic atrophic gastritis
KW - Operative Link for Gastritis Assessment Staging System
KW - Serological test
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U2 - 10.3892/mmr.2015.3872
DO - 10.3892/mmr.2015.3872
M3 - Article
C2 - 26035809
AN - SCOPUS:84935415547
VL - 12
SP - 3521
EP - 3524
JO - Molecular Medicine Reports
JF - Molecular Medicine Reports
SN - 1791-2997
IS - 3
ER -