Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia

Francesco Spallotta, Silvia Tardivo, Simona Nanni, Jessica D. Rosati, Stefania Straino, Antonello Mai, Matteo Vecellio, Sergio Valente, Maurizio C. Capogrossi, Antonella Farsetti, Julie Martone, Irene Bozzoni, Alfredo Pontecorvi, Carlo Gaetano, Claudia Colussi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: No information is available about the effect of class-selective histone deacetylase inhibitors (DIs) following hindlimb ischemia. Results: Class I and class IIa DIs prevent/delay ischemic muscle reconstruction at different stages. Conclusion: Evidence is provided about a detrimental effect of DIs during normal muscle regeneration. Significance: The therapeutic relevance of class-selective DIs in hindlimb ischemia may be limited by adverse effects.

Original languageEnglish
Pages (from-to)22915-22929
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number32
DOIs
Publication statusPublished - Aug 9 2013

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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