Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units. Protocol of the FUNgal infections Definitions in ICU patients (FUNDICU) project

Matteo Bassetti, Luigia Scudeller, Daniele R Giacobbe, Frederic Lamoth, Elda Righi, Valentina Zuccaro, Cecilia Grecchi, Chiara Rebuffi, Murat Akova, Ana Alastruey-Izquierdo, Sevtap Arikan-Akdagli, Elie Azoulay, Stijn I Blot, Oliver A Cornely, Cornelia Lass-Flörl, Philipp Koehler, Manuel Cuenca-Estrella, Dylan W de Lange, Francesco G De Rosa, Jan J De WaeleGeorge Dimopoulos, José Garnacho-Montero, Martin Hoenigl, Souha S Kanj, Johan Maertens, Ignacio Martin-Loeches, Patricia Muñoz, Bart J Kullberg, Christina Agvald-Ohman, Garyphallia Poulakou, Jordi Rello, Maurizio Sanguinetti, Fabio S Taccone, Jean-François Timsit, Antoni Torres, Jose A Vazquez, Thierry Calandra, from the Study Group for Infections in Critically Ill Patients (ESGCIP) and the Fungal Infection Study Group (EFISG) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), European Society of Intensive Care Medicine (ESICM), European Confederation of Medical Mycology (ECMM), Mycoses Study Group Education and Research Consortium (MSGERC)

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The reliability of diagnostic criteria for invasive fungal diseases (IFD) developed for severely immunocompromised patients is questionable in critically ill adult patients in intensive care units (ICU). OBJECTIVES: To develop a standard set of definitions for IFD in critically ill adult patients in ICU. METHODS: Based on a systematic literature review, a list of potential definitions to be applied to ICU patients will be developed by the ESCMID Study Group for Infections in Critically Ill Patients (ESGCIP) and the ESCMID Fungal Infection Study Group (EFISG) chairpersons. The proposed definitions will be evaluated by a panel of 30 experts using the RAND/UCLA appropriateness methods. The panel will rank each of the proposed definitions on a 1-9 scale trough a dedicated questionnaire, in two rounds: one remote and one face-to-face. Based on their median rank and the level of agreement across panel members, selected definitions will be organised in a main consensus document and in an executive summary. The executive summary will be made available online for public comments. CONCLUSIONS: The present consensus project will seek to provide standard definitions for IFD in critically ill adult patients in ICU, with the ultimate aims of improving their clinical outcome and facilitating the comparison and generalizability of research findings.
Original languageEnglish
Pages (from-to)310-319
Number of pages10
JournalMycoses
Volume62
Issue number4
DOIs
Publication statusPublished - Apr 2019

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Keywords

  • Aspergillus
  • Candida
  • biomarker
  • candidiasis
  • cryptococcosis
  • diagnosis
  • pneumocystosis
  • Consensus
  • *Critical Illness
  • Humans
  • *Intensive Care Units
  • Invasive Fungal Infections/*diagnosis/*pathology
  • *Terminology as Topic

Cite this

Bassetti, M., Scudeller, L., Giacobbe, D. R., Lamoth, F., Righi, E., Zuccaro, V., Grecchi, C., Rebuffi, C., Akova, M., Alastruey-Izquierdo, A., Arikan-Akdagli, S., Azoulay, E., Blot, S. I., Cornely, O. A., Lass-Flörl, C., Koehler, P., Cuenca-Estrella, M., de Lange, D. W., De Rosa, F. G., ... (MSGERC), M. S. G. E. A. R. C. (2019). Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units. Protocol of the FUNgal infections Definitions in ICU patients (FUNDICU) project. Mycoses, 62(4), 310-319. https://doi.org/10.1111/myc.12869