Development and applications of surface-activated chemical ionization

Simone Cristoni; Simone Rubini; Luigi Rossi Bernardi

doi:10.1002/mas.20143

Development and applications of surface-activated chemical ionization

Simone Cristoni, Simone Rubini, Luigi Rossi Bernardi

IRCCS Multimedica

Research output: Contribution to journal › Article

Abstract

This review regards the recently developed ionization source named surface-activated chemical ionization (SACI) that employs an interaction with a surface placed at low voltage for the activation of the ionization of sample molecules to increase the sensitivity in the analysis of various compounds of biological and clinical interest. These results are due to the strong chemical noise decrease and the increase of ionization efficiency. This ionization source has been employed for the analysis of various compounds of different molecular mass and polarity (addicted and pharmaceutical drugs, aminoacids, steroids, peptides, and proteins). The SACI development theoretical mechanism, benefits, disadvantages, applications, and future developments are reported and discussed.

Original language	English
Pages (from-to)	645-656
Number of pages	12
Journal	Mass Spectrometry Reviews
Volume	26
Issue number	5
DOIs	https://doi.org/10.1002/mas.20143
Publication status	Published - Sep 2007

Keywords

Drugs
Ionization source
Mass spectrometry
Peptides
SACI
Surface activated chemical ionization

ASJC Scopus subject areas

Spectroscopy

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Cristoni, S., Rubini, S., & Bernardi, L. R. (2007). Development and applications of surface-activated chemical ionization. Mass Spectrometry Reviews, 26(5), 645-656. https://doi.org/10.1002/mas.20143

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