Development and applications of surface-activated chemical ionization

Simone Cristoni, Simone Rubini, Luigi Rossi Bernardi

Research output: Contribution to journalArticlepeer-review


This review regards the recently developed ionization source named surface-activated chemical ionization (SACI) that employs an interaction with a surface placed at low voltage for the activation of the ionization of sample molecules to increase the sensitivity in the analysis of various compounds of biological and clinical interest. These results are due to the strong chemical noise decrease and the increase of ionization efficiency. This ionization source has been employed for the analysis of various compounds of different molecular mass and polarity (addicted and pharmaceutical drugs, aminoacids, steroids, peptides, and proteins). The SACI development theoretical mechanism, benefits, disadvantages, applications, and future developments are reported and discussed.

Original languageEnglish
Pages (from-to)645-656
Number of pages12
JournalMass Spectrometry Reviews
Issue number5
Publication statusPublished - Sep 2007


  • Drugs
  • Ionization source
  • Mass spectrometry
  • Peptides
  • SACI
  • Surface activated chemical ionization

ASJC Scopus subject areas

  • Spectroscopy


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