Development and definition of a simplified scanning procedure and scoring method for Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US)

Carlo Martinoli, Ornella Della Casa Alberighi, Giovanni Di Minno, Ermelinda Graziano, Angelo Claudio Molinari, Gianluigi Pasta, Giuseppe Russo, Elena Santagostino, Annarita Tagliaferri, Alberto Tagliafico, Massimo Morfini

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The aim of this study was to develop a simplified ultrasound scanning procedure and scoring method, named Haemophilia Early Arthropathy Detection with UltraSound [HEAD-US], to evaluate joints of patients with haemophilic arthropathy. After an initial consensus-based process involving a multidisciplinary panel of experts, three comprehensive and evidence-based US scanning procedures to image the elbow, knee and ankle were established with the aim to increase sensitivity in detection of early signs of joint involvement while keeping the technique easy and quick to perform. Each procedure included systematic evaluation of synovial recesses and selection of a single osteochondral surface for damage analysis. Based on expert consensus, a simplified scoring system based on an additive scale was created to define the joint status and, in perspective, to offer a tool to evaluate disease progression and monitor the result of treatment in follow-up studies.

Original languageEnglish
Pages (from-to)1170-1179
Number of pages10
JournalThrombosis and Haemostasis
Volume109
Issue number6
DOIs
Publication statusPublished - Apr 4 2013

Fingerprint

Joint Diseases
Hemophilia A
Research Design
Joints
Elbow
Ankle
Disease Progression
Knee
Therapeutics

Keywords

  • Haemophilic arthropathy
  • Joints
  • Osteochondral damage
  • Scoring systems
  • Synovitis
  • Ultrasonography

ASJC Scopus subject areas

  • Hematology

Cite this

Development and definition of a simplified scanning procedure and scoring method for Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US). / Martinoli, Carlo; Casa Alberighi, Ornella Della; Di Minno, Giovanni; Graziano, Ermelinda; Claudio Molinari, Angelo; Pasta, Gianluigi; Russo, Giuseppe; Santagostino, Elena; Tagliaferri, Annarita; Tagliafico, Alberto; Morfini, Massimo.

In: Thrombosis and Haemostasis, Vol. 109, No. 6, 04.04.2013, p. 1170-1179.

Research output: Contribution to journalArticle

Martinoli, Carlo ; Casa Alberighi, Ornella Della ; Di Minno, Giovanni ; Graziano, Ermelinda ; Claudio Molinari, Angelo ; Pasta, Gianluigi ; Russo, Giuseppe ; Santagostino, Elena ; Tagliaferri, Annarita ; Tagliafico, Alberto ; Morfini, Massimo. / Development and definition of a simplified scanning procedure and scoring method for Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US). In: Thrombosis and Haemostasis. 2013 ; Vol. 109, No. 6. pp. 1170-1179.
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