Development and external validation of nomograms predicting disease-free and cancer-specific survival after radical cystectomy

Giuseppe Simone, Marco Bianchi, Diana Giannarelli, Siamak Daneshmand, Rocco Papalia, Mariaconsiglia Ferriero, Salvatore Guaglianone, Steno Sentinelli, Renzo Colombo, Francesco Montorsi, Devis Collura, Giovanni Muto, Giacomo Novara, Rodolfo Hurle, Michael Rink, Margit Fisch, Hassan Abol-Enein, Gus Miranda, Mihir Desai, Inderbir GillMichele Gallucci

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To develop two nomograms predicting disease-free survival (DFS) and cancer-specific survival (CSS) and to externally validate them in multiple series. Methods: Prospectively collected data from a single-centre series of 818 consecutive patients who underwent RC and PLND were used to build the nomogram. External validation was performed in 3,173 patients from 7 centres worldwide. Time to recurrence and to cancer-specific death were addressed with univariable and multivariable analyses. Nomograms were built to predict 2-, 5- and 8-year DFS and CSS probabilities. Predictive accuracy was quantified using the concordance index. Results: Age, pathologic T stage, lymph-node density and extent of PLND were independent predictors of DFS and CSS (p 

Original languageEnglish
Pages (from-to)1419-1428
Number of pages10
JournalWorld Journal of Urology
Volume33
Issue number10
DOIs
Publication statusPublished - Oct 30 2015

Keywords

  • Nomogram
  • Prediction
  • Radical cystectomy
  • Survival
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Development and external validation of nomograms predicting disease-free and cancer-specific survival after radical cystectomy'. Together they form a unique fingerprint.

Cite this