TY - JOUR
T1 - Development and external validation of nomograms predicting disease-free and cancer-specific survival after radical cystectomy
AU - Simone, Giuseppe
AU - Bianchi, Marco
AU - Giannarelli, Diana
AU - Daneshmand, Siamak
AU - Papalia, Rocco
AU - Ferriero, Mariaconsiglia
AU - Guaglianone, Salvatore
AU - Sentinelli, Steno
AU - Colombo, Renzo
AU - Montorsi, Francesco
AU - Collura, Devis
AU - Muto, Giovanni
AU - Novara, Giacomo
AU - Hurle, Rodolfo
AU - Rink, Michael
AU - Fisch, Margit
AU - Abol-Enein, Hassan
AU - Miranda, Gus
AU - Desai, Mihir
AU - Gill, Inderbir
AU - Gallucci, Michele
PY - 2015/10/30
Y1 - 2015/10/30
N2 - Purpose: To develop two nomograms predicting disease-free survival (DFS) and cancer-specific survival (CSS) and to externally validate them in multiple series. Methods: Prospectively collected data from a single-centre series of 818 consecutive patients who underwent RC and PLND were used to build the nomogram. External validation was performed in 3,173 patients from 7 centres worldwide. Time to recurrence and to cancer-specific death were addressed with univariable and multivariable analyses. Nomograms were built to predict 2-, 5- and 8-year DFS and CSS probabilities. Predictive accuracy was quantified using the concordance index. Results: Age, pathologic T stage, lymph-node density and extent of PLND were independent predictors of DFS and CSS (p
AB - Purpose: To develop two nomograms predicting disease-free survival (DFS) and cancer-specific survival (CSS) and to externally validate them in multiple series. Methods: Prospectively collected data from a single-centre series of 818 consecutive patients who underwent RC and PLND were used to build the nomogram. External validation was performed in 3,173 patients from 7 centres worldwide. Time to recurrence and to cancer-specific death were addressed with univariable and multivariable analyses. Nomograms were built to predict 2-, 5- and 8-year DFS and CSS probabilities. Predictive accuracy was quantified using the concordance index. Results: Age, pathologic T stage, lymph-node density and extent of PLND were independent predictors of DFS and CSS (p
KW - Nomogram
KW - Prediction
KW - Radical cystectomy
KW - Survival
KW - Urothelial carcinoma
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U2 - 10.1007/s00345-014-1465-4
DO - 10.1007/s00345-014-1465-4
M3 - Article
C2 - 25542395
AN - SCOPUS:84942519184
VL - 33
SP - 1419
EP - 1428
JO - World Journal of Urology
JF - World Journal of Urology
SN - 0724-4983
IS - 10
ER -