TY - JOUR
T1 - Development and initial validation of a composite disease activity score for systemic juvenile idiopathic arthritis
AU - Tibaldi, Jessica
AU - Pistorio, Angela
AU - Aldera, Elena
AU - Puzone, Laura
AU - El Miedany, Yasser
AU - Pal, Priyankar
AU - Giri, Prabhas Prasun
AU - De, Hriday
AU - Khubchandani, Raju
AU - Chavan, Pallavi Pimpale
AU - Vilaiyuk, Soamarat
AU - Lerkvaleekul, Butsabong
AU - Yamsuwan, Jutamas
AU - Sabui, Tapas K.
AU - Datta, Pragati
AU - Pardeo, Manuela
AU - Bracaglia, Claudia
AU - Sawhney, Sujata
AU - Mittal, Sumidha
AU - Hassan, Waleed A.
AU - Elderiny, Ghada Farouk
AU - Abu-Zaid, Mohammed Hassan
AU - Eissa, Mervat
AU - Sztajnbok, Flavio
AU - das Neves Sztajnbok, Fernanda C.
AU - Russo, Ricardo
AU - Katsicas, María Martha
AU - Cimaz, Rolando
AU - Marrani, Edoardo
AU - Alexeeva, Ekaterina
AU - Dvoryakovskaya, Tatyana M.
AU - Alsuweiti, Motasem O.
AU - Alzyoud, Ra'ed M.
AU - Kostik, Mikhail
AU - Chikova, Irina
AU - Minoia, Francesca
AU - Filocamo, Giovanni
AU - Farag, Yomna
AU - Lotfy, Hala
AU - Nasef, Samah Ismail
AU - Al-Mayouf, Sulaiman M.
AU - Maggio, Maria Cristina
AU - Magalhaes, Claudia Saad
AU - Gallizzi, Romina
AU - Conti, Giovanni
AU - Shimizu, Masaki
AU - Giancane, Gabriella
AU - Ruperto, Nicolino
AU - Consolaro, Alessandro
AU - Ravelli, Angelo
N1 - Publisher Copyright:
© The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.
Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2020/11/1
Y1 - 2020/11/1
N2 - OBJECTIVE: To develop a composite disease activity score for systemic JIA (sJIA) and to provide preliminary evidence of its validity. METHODS: The systemic Juvenile Arthritis Disease Activity Score (sJADAS) was constructed by adding to the four items of the original JADAS a fifth item that aimed to quantify the activity of systemic features. Validation analyses were conducted on patients with definite or probable/possible sJIA enrolled at first visit or at the time of a flare, who had active systemic manifestations, which should include fever. Patients were reassessed 2 weeks to 3 months after baseline. Three versions were examined, including ESR, CRP or no acute-phase reactant. RESULTS: A total of 163 patients were included at 30 centres in 10 countries. The sJADAS was found to be feasible and to possess face and content validity, good construct validity, satisfactory internal consistency (Cronbach's alpha 0.64-0.65), fair ability to discriminate between patients with different disease activity states and between those whose parents were satisfied or not satisfied with illness outcome (P < 0.0001 for both), and strong responsiveness to change over time (standardized response mean 2.04-2.58). Overall, these properties were found to be better than those of the original JADAS and of DAS for RA and of Puchot score for adult-onset Still's disease. CONCLUSION: The sJADAS showed good measurement properties and is therefore a valid instrument for the assessment of disease activity in children with sJIA. The performance of the new tool should be further examined in other patient cohorts that are evaluated prospectively.
AB - OBJECTIVE: To develop a composite disease activity score for systemic JIA (sJIA) and to provide preliminary evidence of its validity. METHODS: The systemic Juvenile Arthritis Disease Activity Score (sJADAS) was constructed by adding to the four items of the original JADAS a fifth item that aimed to quantify the activity of systemic features. Validation analyses were conducted on patients with definite or probable/possible sJIA enrolled at first visit or at the time of a flare, who had active systemic manifestations, which should include fever. Patients were reassessed 2 weeks to 3 months after baseline. Three versions were examined, including ESR, CRP or no acute-phase reactant. RESULTS: A total of 163 patients were included at 30 centres in 10 countries. The sJADAS was found to be feasible and to possess face and content validity, good construct validity, satisfactory internal consistency (Cronbach's alpha 0.64-0.65), fair ability to discriminate between patients with different disease activity states and between those whose parents were satisfied or not satisfied with illness outcome (P < 0.0001 for both), and strong responsiveness to change over time (standardized response mean 2.04-2.58). Overall, these properties were found to be better than those of the original JADAS and of DAS for RA and of Puchot score for adult-onset Still's disease. CONCLUSION: The sJADAS showed good measurement properties and is therefore a valid instrument for the assessment of disease activity in children with sJIA. The performance of the new tool should be further examined in other patient cohorts that are evaluated prospectively.
KW - clinical assessment
KW - composite disease activity score
KW - disease activity
KW - outcome measures
KW - pediatric rheumatology
KW - Still’s disease
KW - systemic juvenile idiopathic arthritis
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U2 - 10.1093/rheumatology/keaa240
DO - 10.1093/rheumatology/keaa240
M3 - Article
C2 - 32829413
AN - SCOPUS:85094932332
VL - 59
SP - 3505
EP - 3514
JO - Rheumatology
JF - Rheumatology
SN - 1462-0324
IS - 11
ER -