Development and validation of a patient-reported outcome measure in vitiligo: The Self Assessment Vitiligo Extent Score (SA-VES)

Nanja van Geel, Janny E. Lommerts, Marcel W. Bekkenk, Cecilia A C Prinsen, Viktoria Eleftheriadou, Alain Taieb, Mauro Picardo, Khaled Ezzedine, Albert Wolkerstorfer, Reinhart Speeckaert

Research output: Contribution to journalArticle

Abstract

Background: The Vitiligo Extent Score (VES) has recently been introduced as a physicians' score for the clinical assessment of the extent of vitiligo, but a good patient self-assessment score is lacking. Objective: The objective is to develop and validate a simplified version of the VES as a patient-reported outcome measure (PROM). Methods: After extensive pilot testing, patients were asked to score their vitiligo extent twice with an interval of 2 weeks using the Self Assessment Vitiligo Extent Score (SA-VES). The scores were compared with the physicians' evaluation (VES). Results: The SA-VES demonstrated very good test-retest reliability (intraclass correlation = 0.948, 95% confidence interval [CI]: 0.911-0.970) that was not affected by age, skin type, or vitiligo distribution pattern. According to patients, this evaluation method was easy to use (22% very easy; 49% easy; 29% normal) and required <5 minutes in the majority of patients (73%, <5 minutes; 24%, 5-10 minutes; 2%, 10-15 minutes). Comparison of the SA-VES and the VES demonstrated excellent correlation (r = 0.986, . P <.001). Limitations: Few patients had a dark skin type. Conclusion: The results demonstrate excellent reliability of the SA-VES and excellent correlation with its investigator-reported counterpart (VES). This patient-oriented evaluation method provides a useful tool for the assessment of vitiligo extent.

Original languageEnglish
JournalJournal of the American Academy of Dermatology
DOIs
Publication statusAccepted/In press - 2016

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Vitiligo
Self-Assessment
Patient Reported Outcome Measures
Physicians
Skin
Reproducibility of Results

Keywords

  • Body surface area
  • Outcome measurement
  • Patient-reported outcomes
  • Severity
  • Vitiligo

ASJC Scopus subject areas

  • Dermatology

Cite this

Development and validation of a patient-reported outcome measure in vitiligo : The Self Assessment Vitiligo Extent Score (SA-VES). / van Geel, Nanja; Lommerts, Janny E.; Bekkenk, Marcel W.; Prinsen, Cecilia A C; Eleftheriadou, Viktoria; Taieb, Alain; Picardo, Mauro; Ezzedine, Khaled; Wolkerstorfer, Albert; Speeckaert, Reinhart.

In: Journal of the American Academy of Dermatology, 2016.

Research output: Contribution to journalArticle

van Geel, Nanja ; Lommerts, Janny E. ; Bekkenk, Marcel W. ; Prinsen, Cecilia A C ; Eleftheriadou, Viktoria ; Taieb, Alain ; Picardo, Mauro ; Ezzedine, Khaled ; Wolkerstorfer, Albert ; Speeckaert, Reinhart. / Development and validation of a patient-reported outcome measure in vitiligo : The Self Assessment Vitiligo Extent Score (SA-VES). In: Journal of the American Academy of Dermatology. 2016.
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abstract = "Background: The Vitiligo Extent Score (VES) has recently been introduced as a physicians' score for the clinical assessment of the extent of vitiligo, but a good patient self-assessment score is lacking. Objective: The objective is to develop and validate a simplified version of the VES as a patient-reported outcome measure (PROM). Methods: After extensive pilot testing, patients were asked to score their vitiligo extent twice with an interval of 2 weeks using the Self Assessment Vitiligo Extent Score (SA-VES). The scores were compared with the physicians' evaluation (VES). Results: The SA-VES demonstrated very good test-retest reliability (intraclass correlation = 0.948, 95{\%} confidence interval [CI]: 0.911-0.970) that was not affected by age, skin type, or vitiligo distribution pattern. According to patients, this evaluation method was easy to use (22{\%} very easy; 49{\%} easy; 29{\%} normal) and required <5 minutes in the majority of patients (73{\%}, <5 minutes; 24{\%}, 5-10 minutes; 2{\%}, 10-15 minutes). Comparison of the SA-VES and the VES demonstrated excellent correlation (r = 0.986, . P <.001). Limitations: Few patients had a dark skin type. Conclusion: The results demonstrate excellent reliability of the SA-VES and excellent correlation with its investigator-reported counterpart (VES). This patient-oriented evaluation method provides a useful tool for the assessment of vitiligo extent.",
keywords = "Body surface area, Outcome measurement, Patient-reported outcomes, Severity, Vitiligo",
author = "{van Geel}, Nanja and Lommerts, {Janny E.} and Bekkenk, {Marcel W.} and Prinsen, {Cecilia A C} and Viktoria Eleftheriadou and Alain Taieb and Mauro Picardo and Khaled Ezzedine and Albert Wolkerstorfer and Reinhart Speeckaert",
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T2 - The Self Assessment Vitiligo Extent Score (SA-VES)

AU - van Geel, Nanja

AU - Lommerts, Janny E.

AU - Bekkenk, Marcel W.

AU - Prinsen, Cecilia A C

AU - Eleftheriadou, Viktoria

AU - Taieb, Alain

AU - Picardo, Mauro

AU - Ezzedine, Khaled

AU - Wolkerstorfer, Albert

AU - Speeckaert, Reinhart

PY - 2016

Y1 - 2016

N2 - Background: The Vitiligo Extent Score (VES) has recently been introduced as a physicians' score for the clinical assessment of the extent of vitiligo, but a good patient self-assessment score is lacking. Objective: The objective is to develop and validate a simplified version of the VES as a patient-reported outcome measure (PROM). Methods: After extensive pilot testing, patients were asked to score their vitiligo extent twice with an interval of 2 weeks using the Self Assessment Vitiligo Extent Score (SA-VES). The scores were compared with the physicians' evaluation (VES). Results: The SA-VES demonstrated very good test-retest reliability (intraclass correlation = 0.948, 95% confidence interval [CI]: 0.911-0.970) that was not affected by age, skin type, or vitiligo distribution pattern. According to patients, this evaluation method was easy to use (22% very easy; 49% easy; 29% normal) and required <5 minutes in the majority of patients (73%, <5 minutes; 24%, 5-10 minutes; 2%, 10-15 minutes). Comparison of the SA-VES and the VES demonstrated excellent correlation (r = 0.986, . P <.001). Limitations: Few patients had a dark skin type. Conclusion: The results demonstrate excellent reliability of the SA-VES and excellent correlation with its investigator-reported counterpart (VES). This patient-oriented evaluation method provides a useful tool for the assessment of vitiligo extent.

AB - Background: The Vitiligo Extent Score (VES) has recently been introduced as a physicians' score for the clinical assessment of the extent of vitiligo, but a good patient self-assessment score is lacking. Objective: The objective is to develop and validate a simplified version of the VES as a patient-reported outcome measure (PROM). Methods: After extensive pilot testing, patients were asked to score their vitiligo extent twice with an interval of 2 weeks using the Self Assessment Vitiligo Extent Score (SA-VES). The scores were compared with the physicians' evaluation (VES). Results: The SA-VES demonstrated very good test-retest reliability (intraclass correlation = 0.948, 95% confidence interval [CI]: 0.911-0.970) that was not affected by age, skin type, or vitiligo distribution pattern. According to patients, this evaluation method was easy to use (22% very easy; 49% easy; 29% normal) and required <5 minutes in the majority of patients (73%, <5 minutes; 24%, 5-10 minutes; 2%, 10-15 minutes). Comparison of the SA-VES and the VES demonstrated excellent correlation (r = 0.986, . P <.001). Limitations: Few patients had a dark skin type. Conclusion: The results demonstrate excellent reliability of the SA-VES and excellent correlation with its investigator-reported counterpart (VES). This patient-oriented evaluation method provides a useful tool for the assessment of vitiligo extent.

KW - Body surface area

KW - Outcome measurement

KW - Patient-reported outcomes

KW - Severity

KW - Vitiligo

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