Development of a Certified Reference Material for myeloperoxidase-anti-neutrophil cytoplasmic autoantibodies (MPO-ANCA)

Evanthia Monogioudi, Dana Petronela Hutu, Gustavo Martos, Joanna Sheldon, Heinz Schimmel, Pier Luigi Meroni, Ingrid Zegers

Research output: Contribution to journalArticle


A serum Certified Reference Material (CRM) for supporting reliable autoimmune diagnostics was recently released by the Institute for Reference Materials and Measurements (IRMM) of the Joint Research Centre of the European Commission. It was produced in collaboration with a Working Group on the Harmonisation of Autoimmune Tests of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC WG-HAT). This material is aimed at facilitating the standardisation of measurements of anti-myeloperoxidase immunoglobulin G antibodies. The CRM could be used as a common calibrant by clinicians and manufacturers thereby significantly improving the comparability of results from commercial immunoassays used for IgG anti-MPO measurements. This paper provides information on the new CRM and its intended use.

Original languageEnglish
JournalClinica Chimica Acta
Publication statusAccepted/In press - Jan 8 2016



  • Certified reference material
  • Myeloperoxidase
  • Standardisation
  • Vasculitis

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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