Development of a Certified Reference Material for myeloperoxidase-anti-neutrophil cytoplasmic autoantibodies (MPO-ANCA)

Evanthia Monogioudi, Dana Petronela Hutu, Gustavo Martos, Joanna Sheldon, Heinz Schimmel, Pier Luigi Meroni, Ingrid Zegers

Research output: Contribution to journalArticle

Abstract

A serum Certified Reference Material (CRM) for supporting reliable autoimmune diagnostics was recently released by the Institute for Reference Materials and Measurements (IRMM) of the Joint Research Centre of the European Commission. It was produced in collaboration with a Working Group on the Harmonisation of Autoimmune Tests of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC WG-HAT). This material is aimed at facilitating the standardisation of measurements of anti-myeloperoxidase immunoglobulin G antibodies. The CRM could be used as a common calibrant by clinicians and manufacturers thereby significantly improving the comparability of results from commercial immunoassays used for IgG anti-MPO measurements. This paper provides information on the new CRM and its intended use.

Original languageEnglish
Pages (from-to)48-50
Number of pages3
JournalClinica Chimica Acta
Volume467
DOIs
Publication statusPublished - Apr 1 2017

Fingerprint

Clinical Chemistry
Immunoassay
Autoantibodies
Peroxidase
Neutrophils
Immunoglobulin G
Medicine
Antibodies
Serum
Research
Clinical laboratories
Standardization
anti-IgG

Keywords

  • Certified reference material
  • Myeloperoxidase
  • Standardisation
  • Vasculitis

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Development of a Certified Reference Material for myeloperoxidase-anti-neutrophil cytoplasmic autoantibodies (MPO-ANCA). / Monogioudi, Evanthia; Hutu, Dana Petronela; Martos, Gustavo; Sheldon, Joanna; Schimmel, Heinz; Meroni, Pier Luigi; Zegers, Ingrid.

In: Clinica Chimica Acta, Vol. 467, 01.04.2017, p. 48-50.

Research output: Contribution to journalArticle

Monogioudi, Evanthia ; Hutu, Dana Petronela ; Martos, Gustavo ; Sheldon, Joanna ; Schimmel, Heinz ; Meroni, Pier Luigi ; Zegers, Ingrid. / Development of a Certified Reference Material for myeloperoxidase-anti-neutrophil cytoplasmic autoantibodies (MPO-ANCA). In: Clinica Chimica Acta. 2017 ; Vol. 467. pp. 48-50.
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