Development of a neurotechnological system for relieving phantom limb pain using transverse intrafascicular electrodes (TIME)

Thomas Stieglitz, Tim Boretius, Xavier Navarro, Jordi Badia, David Guiraud, Jean Louis Divoux, Silvestro Micera, Paolo Maria Rossini, Ken Yoshida, Kristian R. Harreby, Aritra Kundu, Winnie Jensen

Research output: Contribution to journalArticlepeer-review


Phantom limb pain (PLP) is a chronic condition that develops in the majority of amputees. The underlying mechanisms are not completely understood, and thus, no treatment is fully effective. Based on recent studies, we hypothesize that electrical stimulation of afferent nerves might alleviate PLP by giving sensory input to the patient if nerve fibers can be activated selectively. The critical component in this scheme is the implantable electrode structure. We present a review of a novel electrode concept to distribute highly selective electrode contacts over the complete cross section of a peripheral nerve to create a distributed activation of small nerve fiber ensembles at the fascicular level, the transverse intrafascicular multichannel nerve electrode (TIME). The acute and chronic implantations in a small animal model exhibited a good surface and structural biocompatibility as well as excellent selectivity. Implantation studies on large animal models that are closer to human nerve size and anatomical complexity have also been conducted. They proved implant stability and the ability to selectively activate nerve fascicles in a limited proximity to the implant. These encouraging results have opened the way forward for human clinical trials in amputees to investigate the effect of selective electrical stimulation on PLP.

Original languageEnglish
Pages (from-to)457-465
Number of pages9
JournalBiomedizinische Technik
Issue number6
Publication statusPublished - Dec 2012


  • amputation
  • electrical stimulation
  • microsystem
  • nerve
  • neural prosthesis

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine(all)


Dive into the research topics of 'Development of a neurotechnological system for relieving phantom limb pain using transverse intrafascicular electrodes (TIME)'. Together they form a unique fingerprint.

Cite this