TY - JOUR
T1 - Development of a nomogram based on markers of ovarian reserve for the individualisation of the follicle-stimulating hormone starting dose in in vitro fertilisation cycles
AU - La Marca, A.
AU - Papaleo, E.
AU - Grisendi, V.
AU - Argento, C.
AU - Giulini, S.
AU - Volpe, A.
PY - 2012/9
Y1 - 2012/9
N2 - Please cite this paper as: La Marca A, Papaleo E, Grisendi V, Argento C, Giulini S, Volpe A. Development of a nomogram based on markers of ovarian reserve for the individualisation of the follicle-stimulating hormone starting dose in in vitro fertilisation cycles. BJOG 2012;119:1171-1179. Objective To elaborate a nomogram based on markers of ovarian reserve for the calculation of the appropriate starting dose of follicle-stimulating hormone (FSH). Design Cohort study of infertile women. Setting In vitro fertilisation (IVF) unit, University Hospital of Modena, Italy. Population Women aged 18-40 years (n = 346) and undergoing their first IVF cycle. Methods Serum FSH and anti-Müllerian hormone (AMH) measurement. Main outcome measures Development of a model for the prediction of ovarian response to FSH. Results A model based on age, AMH and FSH was able to accurately predict the ovarian sensitivity and accounted for 30% of the variability of ovarian response to FSH. An FSH dosage nomogram was constructed and overall it predicts a starting FSH dose
AB - Please cite this paper as: La Marca A, Papaleo E, Grisendi V, Argento C, Giulini S, Volpe A. Development of a nomogram based on markers of ovarian reserve for the individualisation of the follicle-stimulating hormone starting dose in in vitro fertilisation cycles. BJOG 2012;119:1171-1179. Objective To elaborate a nomogram based on markers of ovarian reserve for the calculation of the appropriate starting dose of follicle-stimulating hormone (FSH). Design Cohort study of infertile women. Setting In vitro fertilisation (IVF) unit, University Hospital of Modena, Italy. Population Women aged 18-40 years (n = 346) and undergoing their first IVF cycle. Methods Serum FSH and anti-Müllerian hormone (AMH) measurement. Main outcome measures Development of a model for the prediction of ovarian response to FSH. Results A model based on age, AMH and FSH was able to accurately predict the ovarian sensitivity and accounted for 30% of the variability of ovarian response to FSH. An FSH dosage nomogram was constructed and overall it predicts a starting FSH dose
KW - Age
KW - anti-Müllerian hormone
KW - assisted reproductive technology
KW - follicle-stimulating hormone
KW - ovarian reserve
KW - starting follicle-stimulating hormone dose
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U2 - 10.1111/j.1471-0528.2012.03412.x
DO - 10.1111/j.1471-0528.2012.03412.x
M3 - Article
C2 - 22805536
AN - SCOPUS:84865142488
VL - 119
SP - 1171
EP - 1179
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
SN - 1470-0328
IS - 10
ER -