Development of a nomogram based on markers of ovarian reserve for the individualisation of the follicle-stimulating hormone starting dose in in vitro fertilisation cycles

A. La Marca, E. Papaleo, V. Grisendi, C. Argento, S. Giulini, A. Volpe

Research output: Contribution to journalArticlepeer-review

Abstract

Please cite this paper as: La Marca A, Papaleo E, Grisendi V, Argento C, Giulini S, Volpe A. Development of a nomogram based on markers of ovarian reserve for the individualisation of the follicle-stimulating hormone starting dose in in vitro fertilisation cycles. BJOG 2012;119:1171-1179. Objective To elaborate a nomogram based on markers of ovarian reserve for the calculation of the appropriate starting dose of follicle-stimulating hormone (FSH). Design Cohort study of infertile women. Setting In vitro fertilisation (IVF) unit, University Hospital of Modena, Italy. Population Women aged 18-40 years (n = 346) and undergoing their first IVF cycle. Methods Serum FSH and anti-Müllerian hormone (AMH) measurement. Main outcome measures Development of a model for the prediction of ovarian response to FSH. Results A model based on age, AMH and FSH was able to accurately predict the ovarian sensitivity and accounted for 30% of the variability of ovarian response to FSH. An FSH dosage nomogram was constructed and overall it predicts a starting FSH dose

Original languageEnglish
Pages (from-to)1171-1179
Number of pages9
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume119
Issue number10
DOIs
Publication statusPublished - Sep 2012

Keywords

  • Age
  • anti-Müllerian hormone
  • assisted reproductive technology
  • follicle-stimulating hormone
  • ovarian reserve
  • starting follicle-stimulating hormone dose

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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