Abstract
The Italian Hub of Population Biobanks (HIBP) includes both ongoing and completed studies that are heterogeneous in both their purpose and in the specimens collected. The heterogeneity in starting conditions makes sharing study data very difficult because of technical, ethical, and collection rights issues that hamper collaboration and synergy. With the aim of overcoming these difficulties and establishing the "proof-of-concept" that sharing studies is achievable among Italian collections, a data-sharing pilot project has been agreed to by HIBP members. Participants agreed to the general methodology and signed a shared Data Transfer Agreement. The biobanks involved were: EURAC (Micros study), CIG (GEHA project), CNESPS (FINE, MATISS, MONICA, OEC1998, ITR (Italian Twin Register), and IPREA studies, and MOLIBANK (Moli-Sani project). Biobank data were uploaded into a common database using a dedicated informatics infrastructure. Demographic data, and anthropometric and hematochemical parameters were shared for each record. Each biobank uploaded into the common database a dataset with a minimum of 1000 subjects, for a total of 5071 records. After a harmonization process, the final dataset included 3882 records. Subjects were grouped into three main geographic areas of Italy (North, Center, and South) and separate analyses were performed for men and women. The 3882 records were analyzed through multivariate logistic regression analysis. Results were expressed as odds ratios with 95% confidence interval. Results show several geographical differences in the lipidemic pattern, mostly regarding cholesterol-HDL, which represents a strong basis for further, deeper sample-based studies. This HIBP pilot study aimed to prove the feasibility of such collaborations and it provides a methodological prototype for future studies based on the participation in the partnership of well-established quality collections.
| Original language | English |
|---|---|
| Pages (from-to) | 225-233 |
| Number of pages | 9 |
| Journal | Biopreservation and Biobanking |
| Volume | 12 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 1 2014 |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology
- Medicine(all)
Cite this
Development of a pilot project on data sharing among partners of the Italian Hub of Population Biobanks (HIBP) : Association between lipid profile and socio-demographic variables. / Napolitano, Mariarosaria; Santoro, Filippo; Puopolo, Maria; Donfancesco, Chiara; Galluzzo, Lucia; De Grandi, Alessandro; Cevenini, Elisa; De Curtis, Amalia; Sevini, Federica; Palmieri, Luigi; Mascalzon, Deborah; Roazzi, Paolo; Scafato, Emanuele; Pramstaller, Peter; Iacoviello, Licia; Donati, Maria B.; Giampaoli, Simona; Franceschi, Claudio; Belardelli, Filippo; Bravo, Elena.
In: Biopreservation and Biobanking, Vol. 12, No. 4, 01.08.2014, p. 225-233.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development of a pilot project on data sharing among partners of the Italian Hub of Population Biobanks (HIBP)
T2 - Association between lipid profile and socio-demographic variables
AU - Napolitano, Mariarosaria
AU - Santoro, Filippo
AU - Puopolo, Maria
AU - Donfancesco, Chiara
AU - Galluzzo, Lucia
AU - De Grandi, Alessandro
AU - Cevenini, Elisa
AU - De Curtis, Amalia
AU - Sevini, Federica
AU - Palmieri, Luigi
AU - Mascalzon, Deborah
AU - Roazzi, Paolo
AU - Scafato, Emanuele
AU - Pramstaller, Peter
AU - Iacoviello, Licia
AU - Donati, Maria B.
AU - Giampaoli, Simona
AU - Franceschi, Claudio
AU - Belardelli, Filippo
AU - Bravo, Elena
PY - 2014/8/1
Y1 - 2014/8/1
N2 - The Italian Hub of Population Biobanks (HIBP) includes both ongoing and completed studies that are heterogeneous in both their purpose and in the specimens collected. The heterogeneity in starting conditions makes sharing study data very difficult because of technical, ethical, and collection rights issues that hamper collaboration and synergy. With the aim of overcoming these difficulties and establishing the "proof-of-concept" that sharing studies is achievable among Italian collections, a data-sharing pilot project has been agreed to by HIBP members. Participants agreed to the general methodology and signed a shared Data Transfer Agreement. The biobanks involved were: EURAC (Micros study), CIG (GEHA project), CNESPS (FINE, MATISS, MONICA, OEC1998, ITR (Italian Twin Register), and IPREA studies, and MOLIBANK (Moli-Sani project). Biobank data were uploaded into a common database using a dedicated informatics infrastructure. Demographic data, and anthropometric and hematochemical parameters were shared for each record. Each biobank uploaded into the common database a dataset with a minimum of 1000 subjects, for a total of 5071 records. After a harmonization process, the final dataset included 3882 records. Subjects were grouped into three main geographic areas of Italy (North, Center, and South) and separate analyses were performed for men and women. The 3882 records were analyzed through multivariate logistic regression analysis. Results were expressed as odds ratios with 95% confidence interval. Results show several geographical differences in the lipidemic pattern, mostly regarding cholesterol-HDL, which represents a strong basis for further, deeper sample-based studies. This HIBP pilot study aimed to prove the feasibility of such collaborations and it provides a methodological prototype for future studies based on the participation in the partnership of well-established quality collections.
AB - The Italian Hub of Population Biobanks (HIBP) includes both ongoing and completed studies that are heterogeneous in both their purpose and in the specimens collected. The heterogeneity in starting conditions makes sharing study data very difficult because of technical, ethical, and collection rights issues that hamper collaboration and synergy. With the aim of overcoming these difficulties and establishing the "proof-of-concept" that sharing studies is achievable among Italian collections, a data-sharing pilot project has been agreed to by HIBP members. Participants agreed to the general methodology and signed a shared Data Transfer Agreement. The biobanks involved were: EURAC (Micros study), CIG (GEHA project), CNESPS (FINE, MATISS, MONICA, OEC1998, ITR (Italian Twin Register), and IPREA studies, and MOLIBANK (Moli-Sani project). Biobank data were uploaded into a common database using a dedicated informatics infrastructure. Demographic data, and anthropometric and hematochemical parameters were shared for each record. Each biobank uploaded into the common database a dataset with a minimum of 1000 subjects, for a total of 5071 records. After a harmonization process, the final dataset included 3882 records. Subjects were grouped into three main geographic areas of Italy (North, Center, and South) and separate analyses were performed for men and women. The 3882 records were analyzed through multivariate logistic regression analysis. Results were expressed as odds ratios with 95% confidence interval. Results show several geographical differences in the lipidemic pattern, mostly regarding cholesterol-HDL, which represents a strong basis for further, deeper sample-based studies. This HIBP pilot study aimed to prove the feasibility of such collaborations and it provides a methodological prototype for future studies based on the participation in the partnership of well-established quality collections.
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U2 - 10.1089/bio.2014.0001
DO - 10.1089/bio.2014.0001
M3 - Article
C2 - 25075723
AN - SCOPUS:84906960880
VL - 12
SP - 225
EP - 233
JO - Biopreservation and Biobanking
JF - Biopreservation and Biobanking
SN - 1947-5535
IS - 4
ER -