Development of a pilot project on data sharing among partners of the Italian Hub of Population Biobanks (HIBP): Association between lipid profile and socio-demographic variables

Mariarosaria Napolitano, Filippo Santoro, Maria Puopolo, Chiara Donfancesco, Lucia Galluzzo, Alessandro De Grandi, Elisa Cevenini, Amalia De Curtis, Federica Sevini, Luigi Palmieri, Deborah Mascalzon, Paolo Roazzi, Emanuele Scafato, Peter Pramstaller, Licia Iacoviello, Maria B. Donati, Simona Giampaoli, Claudio Franceschi, Filippo Belardelli, Elena Bravo

Research output: Contribution to journalArticle

Abstract

The Italian Hub of Population Biobanks (HIBP) includes both ongoing and completed studies that are heterogeneous in both their purpose and in the specimens collected. The heterogeneity in starting conditions makes sharing study data very difficult because of technical, ethical, and collection rights issues that hamper collaboration and synergy. With the aim of overcoming these difficulties and establishing the "proof-of-concept" that sharing studies is achievable among Italian collections, a data-sharing pilot project has been agreed to by HIBP members. Participants agreed to the general methodology and signed a shared Data Transfer Agreement. The biobanks involved were: EURAC (Micros study), CIG (GEHA project), CNESPS (FINE, MATISS, MONICA, OEC1998, ITR (Italian Twin Register), and IPREA studies, and MOLIBANK (Moli-Sani project). Biobank data were uploaded into a common database using a dedicated informatics infrastructure. Demographic data, and anthropometric and hematochemical parameters were shared for each record. Each biobank uploaded into the common database a dataset with a minimum of 1000 subjects, for a total of 5071 records. After a harmonization process, the final dataset included 3882 records. Subjects were grouped into three main geographic areas of Italy (North, Center, and South) and separate analyses were performed for men and women. The 3882 records were analyzed through multivariate logistic regression analysis. Results were expressed as odds ratios with 95% confidence interval. Results show several geographical differences in the lipidemic pattern, mostly regarding cholesterol-HDL, which represents a strong basis for further, deeper sample-based studies. This HIBP pilot study aimed to prove the feasibility of such collaborations and it provides a methodological prototype for future studies based on the participation in the partnership of well-established quality collections.

Original languageEnglish
Pages (from-to)225-233
Number of pages9
JournalBiopreservation and Biobanking
Volume12
Issue number4
DOIs
Publication statusPublished - Aug 1 2014

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Information Dissemination
Transfer Agreement
Demography
Databases
Lipids
Informatics
Data transfer
Regression analysis
HDL Cholesterol
Italy
Population
Logistics
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals
Datasets

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology
  • Medicine(all)

Cite this

Development of a pilot project on data sharing among partners of the Italian Hub of Population Biobanks (HIBP) : Association between lipid profile and socio-demographic variables. / Napolitano, Mariarosaria; Santoro, Filippo; Puopolo, Maria; Donfancesco, Chiara; Galluzzo, Lucia; De Grandi, Alessandro; Cevenini, Elisa; De Curtis, Amalia; Sevini, Federica; Palmieri, Luigi; Mascalzon, Deborah; Roazzi, Paolo; Scafato, Emanuele; Pramstaller, Peter; Iacoviello, Licia; Donati, Maria B.; Giampaoli, Simona; Franceschi, Claudio; Belardelli, Filippo; Bravo, Elena.

In: Biopreservation and Biobanking, Vol. 12, No. 4, 01.08.2014, p. 225-233.

Research output: Contribution to journalArticle

Napolitano, M, Santoro, F, Puopolo, M, Donfancesco, C, Galluzzo, L, De Grandi, A, Cevenini, E, De Curtis, A, Sevini, F, Palmieri, L, Mascalzon, D, Roazzi, P, Scafato, E, Pramstaller, P, Iacoviello, L, Donati, MB, Giampaoli, S, Franceschi, C, Belardelli, F & Bravo, E 2014, 'Development of a pilot project on data sharing among partners of the Italian Hub of Population Biobanks (HIBP): Association between lipid profile and socio-demographic variables', Biopreservation and Biobanking, vol. 12, no. 4, pp. 225-233. https://doi.org/10.1089/bio.2014.0001
Napolitano, Mariarosaria ; Santoro, Filippo ; Puopolo, Maria ; Donfancesco, Chiara ; Galluzzo, Lucia ; De Grandi, Alessandro ; Cevenini, Elisa ; De Curtis, Amalia ; Sevini, Federica ; Palmieri, Luigi ; Mascalzon, Deborah ; Roazzi, Paolo ; Scafato, Emanuele ; Pramstaller, Peter ; Iacoviello, Licia ; Donati, Maria B. ; Giampaoli, Simona ; Franceschi, Claudio ; Belardelli, Filippo ; Bravo, Elena. / Development of a pilot project on data sharing among partners of the Italian Hub of Population Biobanks (HIBP) : Association between lipid profile and socio-demographic variables. In: Biopreservation and Biobanking. 2014 ; Vol. 12, No. 4. pp. 225-233.
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