Development of a simulation environment for Cerenkov luminescence imaging

Marco Pagliazzi, Esther Ciarrocchi, Alberto Del Guerra, Nicola Belcari, Federico Boschi, Antonello E. Spinelli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

In vivo Cerenkov luminescence imaging (CLI) is a demanding application requiring advanced pre-clinical small animal optical imaging devices. Here we propose a Monte Carlo based simulation workflow aimed to improve the development of an efficient Cerenkov optical imager for small animals. Our work makes use of a modular approach by considering open source, freely available or custom built software to solve the forward light propagation problem from source to detector in the following steps: i) simulation of the efficiency of Cerenkov light production of beta-emitting radionuclide in tissue using GEANT4 ii) optical transport of the simulated emitted photons through a precise mouse CT-segmented model using Molecular Optical Simulation Environment (MOSE), iii) free space transport of light from the mouse surface to a CCD sensor and simulation of the system response. Results showed the effects of the choice of lens and sensor based on system characteristics. An internal 90-Y source was simulated considering a mouse phantom and the Cerenkov light detection by a CCD. We conclude that the modular approach presented in this work combines the strengths of the different simulation codes used and thus provides a complete work frame for optical simulations.

Original languageEnglish
Title of host publicationIEEE Nuclear Science Symposium Conference Record
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Print)9781479905348
DOIs
Publication statusPublished - 2013
Event2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013 - Seoul, Korea, Republic of
Duration: Oct 27 2013Nov 2 2013

Other

Other2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013
CountryKorea, Republic of
CitySeoul
Period10/27/1311/2/13

Fingerprint

environment simulation
Luminescence
luminescence
Light
mice
simulation
animals
charge coupled devices
Optical Devices
Molecular Models
Workflow
Optical Imaging
Photons
Radioisotopes
Lenses
sensors
Software
radioactive isotopes
lenses
computer programs

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Pagliazzi, M., Ciarrocchi, E., Del Guerra, A., Belcari, N., Boschi, F., & Spinelli, A. E. (2013). Development of a simulation environment for Cerenkov luminescence imaging. In IEEE Nuclear Science Symposium Conference Record [6829367] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2013.6829367

Development of a simulation environment for Cerenkov luminescence imaging. / Pagliazzi, Marco; Ciarrocchi, Esther; Del Guerra, Alberto; Belcari, Nicola; Boschi, Federico; Spinelli, Antonello E.

IEEE Nuclear Science Symposium Conference Record. Institute of Electrical and Electronics Engineers Inc., 2013. 6829367.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Pagliazzi, M, Ciarrocchi, E, Del Guerra, A, Belcari, N, Boschi, F & Spinelli, AE 2013, Development of a simulation environment for Cerenkov luminescence imaging. in IEEE Nuclear Science Symposium Conference Record., 6829367, Institute of Electrical and Electronics Engineers Inc., 2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013, Seoul, Korea, Republic of, 10/27/13. https://doi.org/10.1109/NSSMIC.2013.6829367
Pagliazzi M, Ciarrocchi E, Del Guerra A, Belcari N, Boschi F, Spinelli AE. Development of a simulation environment for Cerenkov luminescence imaging. In IEEE Nuclear Science Symposium Conference Record. Institute of Electrical and Electronics Engineers Inc. 2013. 6829367 https://doi.org/10.1109/NSSMIC.2013.6829367
Pagliazzi, Marco ; Ciarrocchi, Esther ; Del Guerra, Alberto ; Belcari, Nicola ; Boschi, Federico ; Spinelli, Antonello E. / Development of a simulation environment for Cerenkov luminescence imaging. IEEE Nuclear Science Symposium Conference Record. Institute of Electrical and Electronics Engineers Inc., 2013.
@inproceedings{437fb6a4b018425dbf80c70d6636d693,
title = "Development of a simulation environment for Cerenkov luminescence imaging",
abstract = "In vivo Cerenkov luminescence imaging (CLI) is a demanding application requiring advanced pre-clinical small animal optical imaging devices. Here we propose a Monte Carlo based simulation workflow aimed to improve the development of an efficient Cerenkov optical imager for small animals. Our work makes use of a modular approach by considering open source, freely available or custom built software to solve the forward light propagation problem from source to detector in the following steps: i) simulation of the efficiency of Cerenkov light production of beta-emitting radionuclide in tissue using GEANT4 ii) optical transport of the simulated emitted photons through a precise mouse CT-segmented model using Molecular Optical Simulation Environment (MOSE), iii) free space transport of light from the mouse surface to a CCD sensor and simulation of the system response. Results showed the effects of the choice of lens and sensor based on system characteristics. An internal 90-Y source was simulated considering a mouse phantom and the Cerenkov light detection by a CCD. We conclude that the modular approach presented in this work combines the strengths of the different simulation codes used and thus provides a complete work frame for optical simulations.",
author = "Marco Pagliazzi and Esther Ciarrocchi and {Del Guerra}, Alberto and Nicola Belcari and Federico Boschi and Spinelli, {Antonello E.}",
year = "2013",
doi = "10.1109/NSSMIC.2013.6829367",
language = "English",
isbn = "9781479905348",
booktitle = "IEEE Nuclear Science Symposium Conference Record",
publisher = "Institute of Electrical and Electronics Engineers Inc.",

}

TY - GEN

T1 - Development of a simulation environment for Cerenkov luminescence imaging

AU - Pagliazzi, Marco

AU - Ciarrocchi, Esther

AU - Del Guerra, Alberto

AU - Belcari, Nicola

AU - Boschi, Federico

AU - Spinelli, Antonello E.

PY - 2013

Y1 - 2013

N2 - In vivo Cerenkov luminescence imaging (CLI) is a demanding application requiring advanced pre-clinical small animal optical imaging devices. Here we propose a Monte Carlo based simulation workflow aimed to improve the development of an efficient Cerenkov optical imager for small animals. Our work makes use of a modular approach by considering open source, freely available or custom built software to solve the forward light propagation problem from source to detector in the following steps: i) simulation of the efficiency of Cerenkov light production of beta-emitting radionuclide in tissue using GEANT4 ii) optical transport of the simulated emitted photons through a precise mouse CT-segmented model using Molecular Optical Simulation Environment (MOSE), iii) free space transport of light from the mouse surface to a CCD sensor and simulation of the system response. Results showed the effects of the choice of lens and sensor based on system characteristics. An internal 90-Y source was simulated considering a mouse phantom and the Cerenkov light detection by a CCD. We conclude that the modular approach presented in this work combines the strengths of the different simulation codes used and thus provides a complete work frame for optical simulations.

AB - In vivo Cerenkov luminescence imaging (CLI) is a demanding application requiring advanced pre-clinical small animal optical imaging devices. Here we propose a Monte Carlo based simulation workflow aimed to improve the development of an efficient Cerenkov optical imager for small animals. Our work makes use of a modular approach by considering open source, freely available or custom built software to solve the forward light propagation problem from source to detector in the following steps: i) simulation of the efficiency of Cerenkov light production of beta-emitting radionuclide in tissue using GEANT4 ii) optical transport of the simulated emitted photons through a precise mouse CT-segmented model using Molecular Optical Simulation Environment (MOSE), iii) free space transport of light from the mouse surface to a CCD sensor and simulation of the system response. Results showed the effects of the choice of lens and sensor based on system characteristics. An internal 90-Y source was simulated considering a mouse phantom and the Cerenkov light detection by a CCD. We conclude that the modular approach presented in this work combines the strengths of the different simulation codes used and thus provides a complete work frame for optical simulations.

UR - http://www.scopus.com/inward/record.url?scp=84904203810&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904203810&partnerID=8YFLogxK

U2 - 10.1109/NSSMIC.2013.6829367

DO - 10.1109/NSSMIC.2013.6829367

M3 - Conference contribution

SN - 9781479905348

BT - IEEE Nuclear Science Symposium Conference Record

PB - Institute of Electrical and Electronics Engineers Inc.

ER -