Development of a three-dimensional model for the N-methyl-D-aspartate NR2A subunit

Giovanni Grazioso, Loris Moretti, Leonardo Scapozza, Marco De Amici, Carlo De Micheli

Research output: Contribution to journalArticlepeer-review


NR2 subunits of N-methyl-D-aspartic acid (NMDA) receptors are known to bind the neurotransmitter glutamate, competitive agonists, and antagonists. Since crystallographic data of these proteins are not available, we built a homology model of the ligand binding domain of the NR2A subunit. A consensus binding mode of selected AP5-like NMDA antagonists has been ascertained using molecular docking. The present 3D model gives insights for the design of new NMDA subtype selective compounds.

Original languageEnglish
Pages (from-to)5489-5494
Number of pages6
JournalJournal of Medicinal Chemistry
Issue number17
Publication statusPublished - Aug 25 2005

ASJC Scopus subject areas

  • Organic Chemistry


Dive into the research topics of 'Development of a three-dimensional model for the N-methyl-D-aspartate NR2A subunit'. Together they form a unique fingerprint.

Cite this