Development of a three-dimensional model for the N-methyl-D-aspartate NR2A subunit

Giovanni Grazioso, Loris Moretti, Leonardo Scapozza, Marco De Amici, Carlo De Micheli

Research output: Contribution to journalArticle

Abstract

NR2 subunits of N-methyl-D-aspartic acid (NMDA) receptors are known to bind the neurotransmitter glutamate, competitive agonists, and antagonists. Since crystallographic data of these proteins are not available, we built a homology model of the ligand binding domain of the NR2A subunit. A consensus binding mode of selected AP5-like NMDA antagonists has been ascertained using molecular docking. The present 3D model gives insights for the design of new NMDA subtype selective compounds.

Original languageEnglish
Pages (from-to)5489-5494
Number of pages6
JournalJournal of Medicinal Chemistry
Volume48
Issue number17
DOIs
Publication statusPublished - Aug 25 2005

ASJC Scopus subject areas

  • Organic Chemistry

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    Grazioso, G., Moretti, L., Scapozza, L., De Amici, M., & De Micheli, C. (2005). Development of a three-dimensional model for the N-methyl-D-aspartate NR2A subunit. Journal of Medicinal Chemistry, 48(17), 5489-5494. https://doi.org/10.1021/jm050174x