Development of antibodies against growth hormone (GH) during rhGH therapy in a girl with idiopathic GH deficiency: A case report

Cristina Meazza, Michael Schaab, Sara Pagani, Valeria Calcaterra, Elena Bozzola, Juergen Kratzsch, Mauro Bozzola

Research output: Contribution to journalArticlepeer-review

Abstract

A 12.5-year-old Italian girl was referred to our institute for progressive growth failure from the age of 6 years, with a height of 128.2 cm ( - 3.37 SDS) and a bone age of 9 years. Endocrinological evaluation revealed a partial growth hormone deficiency (GHD) and GH therapy was started at a dosage of 0.25 mg/kg/week. During the first 3 years, she showed an increase in growth rate and experienced pubertal development onset. Then a poor growth rate (2 cm/year 0.43 SDS) was observed, notwithstanding an increase in GH dosage (0.35 mg/kg/ week) and good compliance. We found a positive anti-GH antibody titre (1:1850, cutoff 1/100), confirmed 6 months later (1:2035); the antibodies had low binding capacity (0.63 μg/mL) and were only partially capable of inhibiting the GH effect. However, GH treatment was discontinued, and after 3 months the antibody titre decreased (1:950). In conclusion, we suggest evaluation of anti-GH antibodies in GH-treated idiopathic GHD children in whom growth response decreases after some years of therapy.

Original languageEnglish
Pages (from-to)785-788
Number of pages4
JournalJournal of Pediatric Endocrinology and Metabolism
Volume26
Issue number7-8
DOIs
Publication statusPublished - Aug 2013

Keywords

  • Anti-GH antibodies
  • Growth hormone (GH) deficiency
  • Growth hormone (GH) therapy

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

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