TY - JOUR
T1 - Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies
AU - Gemma, Sandra
AU - Savini, Luisa
AU - Altarelli, Maria
AU - Tripaldi, Pierangela
AU - Chiasserini, Luisa
AU - Coccone, Salvatore Sanna
AU - Kumar, Vinod
AU - Camodeca, Caterina
AU - Campiani, Giuseppe
AU - Novellino, Ettore
AU - Clarizio, Sandra
AU - Delogu, Giovanni
AU - Butini, Stefania
PY - 2009/8/15
Y1 - 2009/8/15
N2 - A series of 4-quinolylhydrazones was synthesized and tested in vitro against Mycobacterium tuberculosis. At a concentration of 6.25 μg/mL, most of the newly synthesized compounds displayed 100% inhibitory activity against M. tuberculosis in cellular assays. Further screening allowed the identification of very potent antitubercular agents. Compound 4c was also tested in a time-course experiment and against mtb clinical isolates, displaying interesting results.
AB - A series of 4-quinolylhydrazones was synthesized and tested in vitro against Mycobacterium tuberculosis. At a concentration of 6.25 μg/mL, most of the newly synthesized compounds displayed 100% inhibitory activity against M. tuberculosis in cellular assays. Further screening allowed the identification of very potent antitubercular agents. Compound 4c was also tested in a time-course experiment and against mtb clinical isolates, displaying interesting results.
KW - Hydrazone
KW - Mycobacterium tuberculosis
KW - Quinoline
UR - http://www.scopus.com/inward/record.url?scp=68149129505&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68149129505&partnerID=8YFLogxK
U2 - 10.1016/j.bmc.2009.06.051
DO - 10.1016/j.bmc.2009.06.051
M3 - Article
C2 - 19620006
AN - SCOPUS:68149129505
VL - 17
SP - 6063
EP - 6072
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
SN - 0968-0896
IS - 16
ER -