Abstract
The cerebellar circuits comprise a limited number of neuronal phenotypes embedded in a defined cytoarchitecture and generated according to specific spatio-temporal patterns. The local GABAergic network is composed of several interneuron phenotypes that play essential roles in information processing by modulating the activity of cerebellar cortical inputs and outputs. A major issue in the study of cerebellar development is to understand the mechanisms that underlie the generation of different interneuron classes and regulate their placement in the cerebellar architecture and integration in the cortico-nuclear network. Recent findings indicate that the variety of cerebellar interneurons derives from a single population of multipotent progenitors whose fate choices are determined by instructive environmental information. Such a strategy, which is unique for the cerebellum along the neuraxis, allows great flexibility in the control of the quality and quantity of GABAergic interneurons that are produced, thus facilitating the adaptive shaping of the cerebellar network to specific functional demands.
| Original language | English |
|---|---|
| Pages (from-to) | 523-529 |
| Number of pages | 7 |
| Journal | Cerebellum |
| Volume | 7 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Dec 2008 |
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Keywords
- Differentiation
- Inhibitory interneurons
- Neurogenesis
- Neuronal specification
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Development of cerebellar GABAergic interneurons : Origin and shaping of the "minibrain" local connections. / Leto, Ketty; Bartolini, Alice; Rossi, Ferdinando.
In: Cerebellum, Vol. 7, No. 4, 12.2008, p. 523-529.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development of cerebellar GABAergic interneurons
T2 - Origin and shaping of the "minibrain" local connections
AU - Leto, Ketty
AU - Bartolini, Alice
AU - Rossi, Ferdinando
PY - 2008/12
Y1 - 2008/12
N2 - The cerebellar circuits comprise a limited number of neuronal phenotypes embedded in a defined cytoarchitecture and generated according to specific spatio-temporal patterns. The local GABAergic network is composed of several interneuron phenotypes that play essential roles in information processing by modulating the activity of cerebellar cortical inputs and outputs. A major issue in the study of cerebellar development is to understand the mechanisms that underlie the generation of different interneuron classes and regulate their placement in the cerebellar architecture and integration in the cortico-nuclear network. Recent findings indicate that the variety of cerebellar interneurons derives from a single population of multipotent progenitors whose fate choices are determined by instructive environmental information. Such a strategy, which is unique for the cerebellum along the neuraxis, allows great flexibility in the control of the quality and quantity of GABAergic interneurons that are produced, thus facilitating the adaptive shaping of the cerebellar network to specific functional demands.
AB - The cerebellar circuits comprise a limited number of neuronal phenotypes embedded in a defined cytoarchitecture and generated according to specific spatio-temporal patterns. The local GABAergic network is composed of several interneuron phenotypes that play essential roles in information processing by modulating the activity of cerebellar cortical inputs and outputs. A major issue in the study of cerebellar development is to understand the mechanisms that underlie the generation of different interneuron classes and regulate their placement in the cerebellar architecture and integration in the cortico-nuclear network. Recent findings indicate that the variety of cerebellar interneurons derives from a single population of multipotent progenitors whose fate choices are determined by instructive environmental information. Such a strategy, which is unique for the cerebellum along the neuraxis, allows great flexibility in the control of the quality and quantity of GABAergic interneurons that are produced, thus facilitating the adaptive shaping of the cerebellar network to specific functional demands.
KW - Differentiation
KW - Inhibitory interneurons
KW - Neurogenesis
KW - Neuronal specification
UR - http://www.scopus.com/inward/record.url?scp=58149092720&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58149092720&partnerID=8YFLogxK
U2 - 10.1007/s12311-008-0079-z
DO - 10.1007/s12311-008-0079-z
M3 - Article
C2 - 19002744
AN - SCOPUS:58149092720
VL - 7
SP - 523
EP - 529
JO - Cerebellum
JF - Cerebellum
SN - 1473-4222
IS - 4
ER -