Translated title of the contribution: Development of drug-resistance in patients with epilepsy followed from the onset

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Aim of the study was to evaluate the prognosis of different epileptic syndromes in patients observed from the onset of epilepsy (within 12 months from the first seizure) and followed prospectively. One hundred seventy-two patients entered the study; according to ILAE classification of epilepsies we made diagnoses of partial idiopathic epilepsy in 22 cases, partial symptomatic or cryptogenic in 59, grand mal during sleep in 20, generalized idiopathic epilepsy in 46 and generalized symptomatic or cryptogenicin 25. Prognosis was evaluated in 161 patients with follow-up duration longer than 1 year. During follow-up 1 12 patients (69.6%) had one or more seizures and in 18 of them (11.2%) seizures became difficult to control. All these patients had symptomatic or cryptogenic epilepsy. partial in 6 cases and generalized in 12. Poor prognosis was significantly correlated with early age of onset, presence of neurological deficits, epileptiform EEG activities at the first examination and with high seizure frequency before treatment. These risk factors must be considered more relevant for partial symptomatic or cryptogenic cases, who appear to be extremely eterogeneous with regard to etiology, age and electroclinical features at the onset.

Translated title of the contributionDevelopment of drug-resistance in patients with epilepsy followed from the onset
Original languageItalian
Pages (from-to)45-49
Number of pages5
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number70-71
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Clinical Neurology


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