Development of GABA and calcium binding proteins immunoreactivity in the rat hippocampus following neonatal anoxia

Elisabetta Dell'Anna, Maria Concetta Geloso, Maria Magareili, Marco Molinari

Research output: Contribution to journalArticle

Abstract

The consequences of neonatal anoxia (N2 100% for 25 min at 30 h after birth) on the rat hippocampus were studied 7-60 days postnatally with immunocytochemistry for γ-aminobutyric acid (GABA), parvalbumin (PV) and calbindin-D28k (CB). In both sham-treated and anoxic rats, GABA immunoreactivity presented a mature expression since early stages, while PV and CB immunoreactivity showed a major postnatal development. In anoxic animals, a significant reduction in the number of hippocampal GABA- immunoreactive neurons was observed at all time-points analysed, a transitory effect on PV immunoreactivity was seen at P7 and P21, while no modifications in the number of CB-immunoreactive neurons could be found. Thus, selective vulnerability of GABA-containing neurons and relative resistance of neurons in which PV or CB immunoreactivity is present or is expressed later, occur in the hippocampus after neonatal anoxia. The role of calcium binding proteins (CBP) in nerve cell protection is discussed.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalNeuroscience Letters
Volume211
Issue number2
DOIs
Publication statusPublished - Jun 21 1996

Keywords

  • γ-Aminobutyric acid
  • Calbindin
  • Development
  • Hippocampus
  • Parvalbumin
  • Perinatal asphyxia
  • Vulnerability

ASJC Scopus subject areas

  • Neuroscience(all)

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