Development of gray matter atrophy in relapsing-remitting multiple sclerosis is not gender dependent

Results of a 5-year follow-up study

Ondrej Dolezal, Tereza Gabelic, Dana Horakova, Niels Bergsland, Michael G. Dwyer, Zdeněk Seidl, Jan Krasensky, Deepa P. Ramasamy, Manuela Vaneckova, Eva Havrdova, Robert Zivadinov

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives The aim of this study was to explore the evolution of MRI related gender differences in patients with relapsing-remitting (RR) multiple sclerosis (MS) who participated in a clinical trial over the 5 years. Methods 181 patients (39 males and 142 females) were assessed for clinical and neuroradiological disease activity over a period of 5 years. Clinical and MRI examination were performed at the baseline, 6, 12, 24, 36, 48 and 60 months. Longitudinal percentage volume changes in whole brain (PBVC), gray matter (PGMVC) white matter (PWMVC) cortex (PCVC), and lateral ventricles (PLVVC) were calculated by using direct methods (SIENA and SIENAX-multitimepoint). Absolute tissue volume changes of subcortical deep GM structures including caudate, putamen, globus pallidus, thalamus, hippocampus, amygdala and nucleus accumbens were estimated using FIRST, a model based segmentation/registration tool. T2 lesion volume (T2-LV) and lesion activity analyses were performed, using a contouring-threshold and subtraction techniques. All clinical and MRI variables were analyzed between males and females. Results Global (PBVC) and tissue specific (PGMVC, PWMVC, PCVC, PLVVC) brain volume changes showed no significant gender differences over the 5-year follow-up period. Although total subcortical deep GM, caudate, putamen, globus palidus, thalamus and nucleus accumbens normalized volumes were significantly larger in male subjects at baseline, the follow-up analysis showed no differences over the 5 years. There were no gender differences in lesion activity or T2-LV changes over the 5 years. Conclusion No MRI lesion, global, tissue specific or regional brain volume gender change differences were found over the 5-year follow-up.

Original languageEnglish
JournalClinical Neurology and Neurosurgery
Volume115
Issue numberSUPPL.1
DOIs
Publication statusPublished - Dec 2013

Fingerprint

Relapsing-Remitting Multiple Sclerosis
Atrophy
Putamen
Nucleus Accumbens
Thalamus
Brain
Subtraction Technique
Globus Pallidus
Lateral Ventricles
Amygdala
Hippocampus
Clinical Trials
Gray Matter

Keywords

  • Brain atrophy
  • Gender
  • Lesion volume and activity
  • MRI
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Development of gray matter atrophy in relapsing-remitting multiple sclerosis is not gender dependent : Results of a 5-year follow-up study. / Dolezal, Ondrej; Gabelic, Tereza; Horakova, Dana; Bergsland, Niels; Dwyer, Michael G.; Seidl, Zdeněk; Krasensky, Jan; Ramasamy, Deepa P.; Vaneckova, Manuela; Havrdova, Eva; Zivadinov, Robert.

In: Clinical Neurology and Neurosurgery, Vol. 115, No. SUPPL.1, 12.2013.

Research output: Contribution to journalArticle

Dolezal, O, Gabelic, T, Horakova, D, Bergsland, N, Dwyer, MG, Seidl, Z, Krasensky, J, Ramasamy, DP, Vaneckova, M, Havrdova, E & Zivadinov, R 2013, 'Development of gray matter atrophy in relapsing-remitting multiple sclerosis is not gender dependent: Results of a 5-year follow-up study', Clinical Neurology and Neurosurgery, vol. 115, no. SUPPL.1. https://doi.org/10.1016/j.clineuro.2013.09.020
Dolezal, Ondrej ; Gabelic, Tereza ; Horakova, Dana ; Bergsland, Niels ; Dwyer, Michael G. ; Seidl, Zdeněk ; Krasensky, Jan ; Ramasamy, Deepa P. ; Vaneckova, Manuela ; Havrdova, Eva ; Zivadinov, Robert. / Development of gray matter atrophy in relapsing-remitting multiple sclerosis is not gender dependent : Results of a 5-year follow-up study. In: Clinical Neurology and Neurosurgery. 2013 ; Vol. 115, No. SUPPL.1.
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title = "Development of gray matter atrophy in relapsing-remitting multiple sclerosis is not gender dependent: Results of a 5-year follow-up study",
abstract = "Objectives The aim of this study was to explore the evolution of MRI related gender differences in patients with relapsing-remitting (RR) multiple sclerosis (MS) who participated in a clinical trial over the 5 years. Methods 181 patients (39 males and 142 females) were assessed for clinical and neuroradiological disease activity over a period of 5 years. Clinical and MRI examination were performed at the baseline, 6, 12, 24, 36, 48 and 60 months. Longitudinal percentage volume changes in whole brain (PBVC), gray matter (PGMVC) white matter (PWMVC) cortex (PCVC), and lateral ventricles (PLVVC) were calculated by using direct methods (SIENA and SIENAX-multitimepoint). Absolute tissue volume changes of subcortical deep GM structures including caudate, putamen, globus pallidus, thalamus, hippocampus, amygdala and nucleus accumbens were estimated using FIRST, a model based segmentation/registration tool. T2 lesion volume (T2-LV) and lesion activity analyses were performed, using a contouring-threshold and subtraction techniques. All clinical and MRI variables were analyzed between males and females. Results Global (PBVC) and tissue specific (PGMVC, PWMVC, PCVC, PLVVC) brain volume changes showed no significant gender differences over the 5-year follow-up period. Although total subcortical deep GM, caudate, putamen, globus palidus, thalamus and nucleus accumbens normalized volumes were significantly larger in male subjects at baseline, the follow-up analysis showed no differences over the 5 years. There were no gender differences in lesion activity or T2-LV changes over the 5 years. Conclusion No MRI lesion, global, tissue specific or regional brain volume gender change differences were found over the 5-year follow-up.",
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T1 - Development of gray matter atrophy in relapsing-remitting multiple sclerosis is not gender dependent

T2 - Results of a 5-year follow-up study

AU - Dolezal, Ondrej

AU - Gabelic, Tereza

AU - Horakova, Dana

AU - Bergsland, Niels

AU - Dwyer, Michael G.

AU - Seidl, Zdeněk

AU - Krasensky, Jan

AU - Ramasamy, Deepa P.

AU - Vaneckova, Manuela

AU - Havrdova, Eva

AU - Zivadinov, Robert

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N2 - Objectives The aim of this study was to explore the evolution of MRI related gender differences in patients with relapsing-remitting (RR) multiple sclerosis (MS) who participated in a clinical trial over the 5 years. Methods 181 patients (39 males and 142 females) were assessed for clinical and neuroradiological disease activity over a period of 5 years. Clinical and MRI examination were performed at the baseline, 6, 12, 24, 36, 48 and 60 months. Longitudinal percentage volume changes in whole brain (PBVC), gray matter (PGMVC) white matter (PWMVC) cortex (PCVC), and lateral ventricles (PLVVC) were calculated by using direct methods (SIENA and SIENAX-multitimepoint). Absolute tissue volume changes of subcortical deep GM structures including caudate, putamen, globus pallidus, thalamus, hippocampus, amygdala and nucleus accumbens were estimated using FIRST, a model based segmentation/registration tool. T2 lesion volume (T2-LV) and lesion activity analyses were performed, using a contouring-threshold and subtraction techniques. All clinical and MRI variables were analyzed between males and females. Results Global (PBVC) and tissue specific (PGMVC, PWMVC, PCVC, PLVVC) brain volume changes showed no significant gender differences over the 5-year follow-up period. Although total subcortical deep GM, caudate, putamen, globus palidus, thalamus and nucleus accumbens normalized volumes were significantly larger in male subjects at baseline, the follow-up analysis showed no differences over the 5 years. There were no gender differences in lesion activity or T2-LV changes over the 5 years. Conclusion No MRI lesion, global, tissue specific or regional brain volume gender change differences were found over the 5-year follow-up.

AB - Objectives The aim of this study was to explore the evolution of MRI related gender differences in patients with relapsing-remitting (RR) multiple sclerosis (MS) who participated in a clinical trial over the 5 years. Methods 181 patients (39 males and 142 females) were assessed for clinical and neuroradiological disease activity over a period of 5 years. Clinical and MRI examination were performed at the baseline, 6, 12, 24, 36, 48 and 60 months. Longitudinal percentage volume changes in whole brain (PBVC), gray matter (PGMVC) white matter (PWMVC) cortex (PCVC), and lateral ventricles (PLVVC) were calculated by using direct methods (SIENA and SIENAX-multitimepoint). Absolute tissue volume changes of subcortical deep GM structures including caudate, putamen, globus pallidus, thalamus, hippocampus, amygdala and nucleus accumbens were estimated using FIRST, a model based segmentation/registration tool. T2 lesion volume (T2-LV) and lesion activity analyses were performed, using a contouring-threshold and subtraction techniques. All clinical and MRI variables were analyzed between males and females. Results Global (PBVC) and tissue specific (PGMVC, PWMVC, PCVC, PLVVC) brain volume changes showed no significant gender differences over the 5-year follow-up period. Although total subcortical deep GM, caudate, putamen, globus palidus, thalamus and nucleus accumbens normalized volumes were significantly larger in male subjects at baseline, the follow-up analysis showed no differences over the 5 years. There were no gender differences in lesion activity or T2-LV changes over the 5 years. Conclusion No MRI lesion, global, tissue specific or regional brain volume gender change differences were found over the 5-year follow-up.

KW - Brain atrophy

KW - Gender

KW - Lesion volume and activity

KW - MRI

KW - Multiple sclerosis

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