Development of new methodologies for the mass spectrometry study of bioorganic macromolecules

Simone Cristoni, Luigi Rossi Bernardi

Research output: Contribution to journalArticlepeer-review


In recent years, mass spectrometry has been increasingly used for the analysis of various macromolecules of biological, biomedical, and biochemical interest. This increase has been made possible by two key developments: the advent of electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) sources. The two new techniques produce a significant increase in mass range and in sensitivity that led to the development of new applications and of new analyzer designs, software, and robotics. This review, apart from the description of the status of mass spectrometry in the analysis of bioorganic macromolecules, is mainly devoted to the illustration of the more recent promising techniques and on their possible future evolution.

Original languageEnglish
Pages (from-to)369-406
Number of pages38
JournalMass Spectrometry Reviews
Issue number6
Publication statusPublished - Nov 2003


  • Bioorganic macromolecules
  • ESI
  • Macromolecules
  • Mass spectrometry
  • No-discharge APCI
  • SSI

ASJC Scopus subject areas

  • Spectroscopy

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