Development of ocular hypertension secondary to tamponade with light versus heavy silicone oil: A systematic review

Vito Romano, Mario Cruciani, Francesco Semeraro, Ciro Costagliola, Mario R. Romano

Research output: Contribution to journalArticlepeer-review


Aim: The intraocular silicone oil (SO) tamponades used in the treatment of retinal detachment (RD) have been associated with a difference ocular hypertension (OH) rate. To clarify, if this complication was associated to use of standard SO (SSO) versus heavy SO (HSO), we performed a systematic review and meta-analysis of comparative study between two kind of SO (standard or light vs. heavy) for the treatment of RD and macular hole, without restriction to study design. Materials and Methods: The methodological quality of two randomized clinical trials (RCTs) were evaluated using the criteria given in the Cochrane Handbook for Systematic Reviews of Intervention, while three non-RCTs were assessed with the Newcastle-Ottawa Scale and Strengthening the Reporting of Observational Studies in Epidemiology checklists. We calculated Mantel-Haenszel risk ratio (RR) with 95% confidence intervals (95% CIs). The primary outcome was the rate of patients with OH treated with SSO compared to HSO. Results: There were a higher number of rates of OH in HSO compared to SSO. This difference was statistically significant with the fixed effect model (Mantel-Haenszel RR; 1.55; 95% CI, 1.06-2.28; P = 0.02) while there was not significative difference with the random effect model (Mantel-Haenszel RR; 1.51; 95% CI, 0.98-2.33; P = 0.06). Conclusion: We noted a trend that points out a higher OH rate in HSO group compared to SSO, but this finding, due to the small size and variable design of studies, needs to be confirmed in well-designed and large size RCTs.

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalIndian Journal of Ophthalmology
Issue number3
Publication statusPublished - Mar 1 2015


  • Glaucoma
  • heavy silicone oil
  • light silicone oil
  • ocular hypertension
  • retinal detachment
  • standard silicone oil

ASJC Scopus subject areas

  • Ophthalmology


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