Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises

Hugh De Lautour; William J. Taylor; Ade Adebajo; Rieke Alten; Ruben Burgos-Vargas; Peter Chapman; Marco A. Cimmino; Geraldo Da Rocha Castelar Pinheiro; Ric Day; Leslie R. Harrold; Philip Helliwell; Matthijs Janssen; Gail Kerr; Arthur Kavanaugh; Dinesh Khanna; Puja P. Khanna; Chingtsai Lin; Worawit Louthrenoo; Geraldine McCarthy; Janitzia Vazquez-Mellado; Ted R. Mikuls; Tuhina Neogi; Alexis Ogdie; Fernando Perez-Ruiz; Naomi Schlesinger; H. Ralph Schumacher; Carlo A. Scirè; Jasvinder A. Singh; Francisca Sivera; Ole Slot; Lisa K. Stamp; Anne Kathrin Tausche; Robert Terkeltaub; Till Uhlig; Mart Van De Laar; Douglas White; Hisashi Yamanaka; Xuejun Zeng; Nicola Dalbeth

doi:10.1002/acr.22741

Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises

Hugh De Lautour, William J. Taylor, Ade Adebajo, Rieke Alten, Ruben Burgos-Vargas, Peter Chapman, Marco A. Cimmino, Geraldo Da Rocha Castelar Pinheiro, Ric Day, Leslie R. Harrold, Philip Helliwell, Matthijs Janssen, Gail Kerr, Arthur Kavanaugh, Dinesh Khanna, Puja P. Khanna, Chingtsai Lin, Worawit Louthrenoo, Geraldine McCarthy, Janitzia Vazquez-MelladoTed R. Mikuls, Tuhina Neogi, Alexis Ogdie, Fernando Perez-Ruiz, Naomi Schlesinger, H. Ralph Schumacher, Carlo A. Scirè, Jasvinder A. Singh, Francisca Sivera, Ole Slot, Lisa K. Stamp, Anne Kathrin Tausche, Robert Terkeltaub, Till Uhlig, Mart Van De Laar, Douglas White, Hisashi Yamanaka, Xuejun Zeng, Nicola Dalbeth

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Objective To establish consensus for potential remission criteria to use in clinical trials of gout. Methods Experts (n = 88) in gout from multiple countries were invited to participate in a web-based questionnaire study. Three rounds of Delphi consensus exercises were conducted using SurveyMonkey, followed by a discrete-choice experiment using 1000Minds software. The exercises focused on identifying domains, definitions for each domain, and the timeframe over which remission should be defined. Results There were 49 respondents (56% response) to the initial survey, with subsequent response rates ranging from 57% to 90%. Consensus was reached for the inclusion of serum urate (98% agreement), flares (96%), tophi (92%), pain (83%), and patient global assessment of disease activity (93%) as measurement domains in remission criteria. Consensus was also reached for domain definitions, including serum urate (

Original language	English
Pages (from-to)	667-672
Number of pages	6
Journal	Arthritis Care and Research
Volume	68
Issue number	5
DOIs	https://doi.org/10.1002/acr.22741
Publication status	Published - May 1 2016

ASJC Scopus subject areas

Rheumatology

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10.1002/acr.22741

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De Lautour, H., Taylor, W. J., Adebajo, A., Alten, R., Burgos-Vargas, R., Chapman, P., Cimmino, M. A., Da Rocha Castelar Pinheiro, G., Day, R., Harrold, L. R., Helliwell, P., Janssen, M., Kerr, G., Kavanaugh, A., Khanna, D., Khanna, P. P., Lin, C., Louthrenoo, W., McCarthy, G., ... Dalbeth, N. (2016). Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises. Arthritis Care and Research, 68(5), 667-672. https://doi.org/10.1002/acr.22741

Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises. / De Lautour, Hugh; Taylor, William J.; Adebajo, Ade; Alten, Rieke; Burgos-Vargas, Ruben; Chapman, Peter; Cimmino, Marco A.; Da Rocha Castelar Pinheiro, Geraldo; Day, Ric; Harrold, Leslie R.; Helliwell, Philip; Janssen, Matthijs; Kerr, Gail; Kavanaugh, Arthur; Khanna, Dinesh; Khanna, Puja P.; Lin, Chingtsai; Louthrenoo, Worawit; McCarthy, Geraldine; Vazquez-Mellado, Janitzia; Mikuls, Ted R.; Neogi, Tuhina; Ogdie, Alexis; Perez-Ruiz, Fernando; Schlesinger, Naomi; Ralph Schumacher, H.; Scirè, Carlo A.; Singh, Jasvinder A.; Sivera, Francisca; Slot, Ole; Stamp, Lisa K.; Tausche, Anne Kathrin; Terkeltaub, Robert; Uhlig, Till; Van De Laar, Mart; White, Douglas; Yamanaka, Hisashi; Zeng, Xuejun; Dalbeth, Nicola.

In: Arthritis Care and Research, Vol. 68, No. 5, 01.05.2016, p. 667-672.

Research output: Contribution to journal › Article › peer-review

De Lautour, H, Taylor, WJ, Adebajo, A, Alten, R, Burgos-Vargas, R, Chapman, P, Cimmino, MA, Da Rocha Castelar Pinheiro, G, Day, R, Harrold, LR, Helliwell, P, Janssen, M, Kerr, G, Kavanaugh, A, Khanna, D, Khanna, PP, Lin, C, Louthrenoo, W, McCarthy, G, Vazquez-Mellado, J, Mikuls, TR, Neogi, T, Ogdie, A, Perez-Ruiz, F, Schlesinger, N, Ralph Schumacher, H, Scirè, CA, Singh, JA, Sivera, F, Slot, O, Stamp, LK, Tausche, AK, Terkeltaub, R, Uhlig, T, Van De Laar, M, White, D, Yamanaka, H, Zeng, X & Dalbeth, N 2016, 'Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises', Arthritis Care and Research, vol. 68, no. 5, pp. 667-672. https://doi.org/10.1002/acr.22741

De Lautour, Hugh ; Taylor, William J. ; Adebajo, Ade ; Alten, Rieke ; Burgos-Vargas, Ruben ; Chapman, Peter ; Cimmino, Marco A. ; Da Rocha Castelar Pinheiro, Geraldo ; Day, Ric ; Harrold, Leslie R. ; Helliwell, Philip ; Janssen, Matthijs ; Kerr, Gail ; Kavanaugh, Arthur ; Khanna, Dinesh ; Khanna, Puja P. ; Lin, Chingtsai ; Louthrenoo, Worawit ; McCarthy, Geraldine ; Vazquez-Mellado, Janitzia ; Mikuls, Ted R. ; Neogi, Tuhina ; Ogdie, Alexis ; Perez-Ruiz, Fernando ; Schlesinger, Naomi ; Ralph Schumacher, H. ; Scirè, Carlo A. ; Singh, Jasvinder A. ; Sivera, Francisca ; Slot, Ole ; Stamp, Lisa K. ; Tausche, Anne Kathrin ; Terkeltaub, Robert ; Uhlig, Till ; Van De Laar, Mart ; White, Douglas ; Yamanaka, Hisashi ; Zeng, Xuejun ; Dalbeth, Nicola. / Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises. In: Arthritis Care and Research. 2016 ; Vol. 68, No. 5. pp. 667-672.

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abstract = "Objective To establish consensus for potential remission criteria to use in clinical trials of gout. Methods Experts (n = 88) in gout from multiple countries were invited to participate in a web-based questionnaire study. Three rounds of Delphi consensus exercises were conducted using SurveyMonkey, followed by a discrete-choice experiment using 1000Minds software. The exercises focused on identifying domains, definitions for each domain, and the timeframe over which remission should be defined. Results There were 49 respondents (56% response) to the initial survey, with subsequent response rates ranging from 57% to 90%. Consensus was reached for the inclusion of serum urate (98% agreement), flares (96%), tophi (92%), pain (83%), and patient global assessment of disease activity (93%) as measurement domains in remission criteria. Consensus was also reached for domain definitions, including serum urate (",

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AU - De Lautour, Hugh

AU - Taylor, William J.

AU - Adebajo, Ade

AU - Alten, Rieke

AU - Burgos-Vargas, Ruben

AU - Chapman, Peter

AU - Cimmino, Marco A.

AU - Da Rocha Castelar Pinheiro, Geraldo

AU - Day, Ric

AU - Harrold, Leslie R.

AU - Helliwell, Philip

AU - Janssen, Matthijs

AU - Kerr, Gail

AU - Kavanaugh, Arthur

AU - Khanna, Dinesh

AU - Khanna, Puja P.

AU - Lin, Chingtsai

AU - Louthrenoo, Worawit

AU - McCarthy, Geraldine

AU - Vazquez-Mellado, Janitzia

AU - Mikuls, Ted R.

AU - Neogi, Tuhina

AU - Ogdie, Alexis

AU - Perez-Ruiz, Fernando

AU - Schlesinger, Naomi

AU - Ralph Schumacher, H.

AU - Scirè, Carlo A.

AU - Singh, Jasvinder A.

AU - Sivera, Francisca

AU - Slot, Ole

AU - Stamp, Lisa K.

AU - Tausche, Anne Kathrin

AU - Terkeltaub, Robert

AU - Uhlig, Till

AU - Van De Laar, Mart

AU - White, Douglas

AU - Yamanaka, Hisashi

AU - Zeng, Xuejun

AU - Dalbeth, Nicola

PY - 2016/5/1

Y1 - 2016/5/1

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Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises

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