Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises

Hugh De Lautour, William J. Taylor, Ade Adebajo, Rieke Alten, Ruben Burgos-Vargas, Peter Chapman, Marco A. Cimmino, Geraldo Da Rocha Castelar Pinheiro, Ric Day, Leslie R. Harrold, Philip Helliwell, Matthijs Janssen, Gail Kerr, Arthur Kavanaugh, Dinesh Khanna, Puja P. Khanna, Chingtsai Lin, Worawit Louthrenoo, Geraldine McCarthy, Janitzia Vazquez-MelladoTed R. Mikuls, Tuhina Neogi, Alexis Ogdie, Fernando Perez-Ruiz, Naomi Schlesinger, H. Ralph Schumacher, Carlo A. Scirè, Jasvinder A. Singh, Francisca Sivera, Ole Slot, Lisa K. Stamp, Anne Kathrin Tausche, Robert Terkeltaub, Till Uhlig, Mart Van De Laar, Douglas White, Hisashi Yamanaka, Xuejun Zeng, Nicola Dalbeth

Research output: Contribution to journalArticlepeer-review

Abstract

Objective To establish consensus for potential remission criteria to use in clinical trials of gout. Methods Experts (n = 88) in gout from multiple countries were invited to participate in a web-based questionnaire study. Three rounds of Delphi consensus exercises were conducted using SurveyMonkey, followed by a discrete-choice experiment using 1000Minds software. The exercises focused on identifying domains, definitions for each domain, and the timeframe over which remission should be defined. Results There were 49 respondents (56% response) to the initial survey, with subsequent response rates ranging from 57% to 90%. Consensus was reached for the inclusion of serum urate (98% agreement), flares (96%), tophi (92%), pain (83%), and patient global assessment of disease activity (93%) as measurement domains in remission criteria. Consensus was also reached for domain definitions, including serum urate (

Original languageEnglish
Pages (from-to)667-672
Number of pages6
JournalArthritis Care and Research
Volume68
Issue number5
DOIs
Publication statusPublished - May 1 2016

ASJC Scopus subject areas

  • Rheumatology

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