Development of rhabdomyosarcoma in HER-2/neu transgenic p53 mutant mice

Patrizia Nanni, Giordano Nicoletti, Carla De Giovanni, Stefania Croci, Annalisa Astolfi, Lorena Landuzzi, Emma Di Carlo, Manuela Iezzi, Piero Musiani, Pier Luigi Lollini

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Rhabdomyosarcomas derive from the skeletal muscle lineage and harbor a variety of genetic and molecular lesions. However, it is not clear which molecular alterations have a pathogenetic role. We show that activation of the HER-2/neu oncogene coupled with inactivation of the oncosuppressor gene p53 causes rhabdomyosarcoma in mice. At the age of 11-21 weeks, all male mice carrying both genetic lesions developed embryonal rhabdomyosarcomas expressing desmin, myosin, and insulin-like growth factor-II, in the genitourinary tract. Our findings led to the hypothesis that the interaction between HER family genes and the p53 pathway might be involved in the origin of human rhabdomyosarcoma.

Original languageEnglish
Pages (from-to)2728-2732
Number of pages5
JournalCancer Research
Volume63
Issue number11
Publication statusPublished - Jun 1 2003

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Rhabdomyosarcoma
p53 Genes
Embryonal Rhabdomyosarcoma
Insulin-Like Growth Factor II
Desmin
Gene Silencing
Myosins
Oncogenes
Molecular Biology
Skeletal Muscle

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Nanni, P., Nicoletti, G., De Giovanni, C., Croci, S., Astolfi, A., Landuzzi, L., ... Lollini, P. L. (2003). Development of rhabdomyosarcoma in HER-2/neu transgenic p53 mutant mice. Cancer Research, 63(11), 2728-2732.

Development of rhabdomyosarcoma in HER-2/neu transgenic p53 mutant mice. / Nanni, Patrizia; Nicoletti, Giordano; De Giovanni, Carla; Croci, Stefania; Astolfi, Annalisa; Landuzzi, Lorena; Di Carlo, Emma; Iezzi, Manuela; Musiani, Piero; Lollini, Pier Luigi.

In: Cancer Research, Vol. 63, No. 11, 01.06.2003, p. 2728-2732.

Research output: Contribution to journalArticle

Nanni, P, Nicoletti, G, De Giovanni, C, Croci, S, Astolfi, A, Landuzzi, L, Di Carlo, E, Iezzi, M, Musiani, P & Lollini, PL 2003, 'Development of rhabdomyosarcoma in HER-2/neu transgenic p53 mutant mice', Cancer Research, vol. 63, no. 11, pp. 2728-2732.
Nanni P, Nicoletti G, De Giovanni C, Croci S, Astolfi A, Landuzzi L et al. Development of rhabdomyosarcoma in HER-2/neu transgenic p53 mutant mice. Cancer Research. 2003 Jun 1;63(11):2728-2732.
Nanni, Patrizia ; Nicoletti, Giordano ; De Giovanni, Carla ; Croci, Stefania ; Astolfi, Annalisa ; Landuzzi, Lorena ; Di Carlo, Emma ; Iezzi, Manuela ; Musiani, Piero ; Lollini, Pier Luigi. / Development of rhabdomyosarcoma in HER-2/neu transgenic p53 mutant mice. In: Cancer Research. 2003 ; Vol. 63, No. 11. pp. 2728-2732.
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