Development of the Paris definition of early Crohn's disease for disease-modification trials: Results of an international expert opinion process

Laurent Peyrin-Biroulet, Vincent Billioud, Geert D'Haens, Remo Panaccione, Brian Feagan, Julian Panés, Silvio Danese, Stefan Schreiber, Haruhiko Ogata, Toshifumi Hibi, Peter D R Higgins, Laurent Beaugerie, Yehuda Chowers, Edouard Louis, Flávio Steinwurz, Walter Reinisch, Paul Rutgeerts, Jean Frédéric Colombel, Simon Travis, William J. Sandborn

Research output: Contribution to journalArticlepeer-review

Abstract

We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen experts on inflammatory bowel diseases held an international expert opinion meeting to discuss and agree on a definition for early CD to be used in disease-modification trials. The process included literature searches for the relevant basic-science and clinical evidence. A published preliminary definition of early CD was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting. The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in CD.

Original languageEnglish
Pages (from-to)1770-1776
Number of pages7
JournalAmerican Journal of Gastroenterology
Volume107
Issue number12
DOIs
Publication statusPublished - Dec 2012

ASJC Scopus subject areas

  • Gastroenterology

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