Developmental changes in optokinetic mechanisms in the absence of unilateral cortical control

M. Concetta Morrone, Janette Atkinson, Giovanni Cioni, Oliver J. Braddick, Adriana Fiorentínì

Research output: Contribution to journalArticlepeer-review

Abstract

ANIMAL models suggest that the asymmetry of monocular optokinetic nystagmus (OKN) in young infants can be explained by a direct pathway from retina to the midbrain nucleus of the optic tract. However, earlier studies with hemispherectomized infants showed no evidence for OKN responses towards the damaged cortex that could be ascribed to this subcortical pathway. In longitudinal testing of two infants with very extensive unilateral cortical damage, we have now shown that OKN responses in both directions do occur before 10 months of age. OKN towards the damaged cortex, indicating functioning of the direct pathways in the absence of cortical control, drops out in the later development. The neural circuitry responsible for OKN in humans appears to undergo a plastic reorganization.

Original languageEnglish
Pages (from-to)2723-2729
Number of pages7
JournalNeuroReport
Volume10
Issue number13
Publication statusPublished - Sep 9 1999

Keywords

  • Eye movements
  • Hemispherectomized patient
  • Infant
  • Optokinetic nystagmus
  • Visual development

ASJC Scopus subject areas

  • Neuroscience(all)

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