Developmental dental aberrations after the dioxin accident in Seveso

Satu Alaluusua, Pier Calderara, Pier Mario Gerthoux, Pirjo Liisa Lukinmaa, Outi Kovero, Larry Needham, Donald G. Patterson, Jouko Tuomisto, Paolo Mocarelli

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Children's developing teeth may be sensitive to environmental dioxins, and in animal studies developing teeth are one of the most sensitive targets of toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Twenty-five years after the dioxin accident in Seveso, Italy, 48 subjects from the contaminated areas (zones A and B) and in patches lightly contaminated (zone R) were recruited for the examination of dental and oral aberrations. Subjects were randomly invited from those exposed in their childhood and for whom frozen serum samples were available. The subjects were frequency matched with 65 subjects from the surrounding non-ABR zone for age, sex, and education. Concentrations of TCDD in previously analyzed plasma samples (zone ABR subjects only) ranged from 23 to 26,000 ng/kg in serum lipid. Ninety-three percent (25 of 27) of the subjects who had developmental enamel defects had been <5 years of age at the time of the accident. The prevalence of defects in this age group was 42% (15 of 36) in zone ABR gubjects and 26% (10 of 39) in zone non-ABR subjects, correlating with serum TCDD levels (p = 0.016). Hypodontia was seen in 12.5% (6 of 48) and 4.6% (3 of 65) of the zone ABR and non-ABR subjects, respectively, also correlating with serum TCDD level (p = 0.05). In conclusion, developmental dental aberrations were associated with childhood exposure to TCDD. In contrast, dental caries and periodontal disease, both infectious in nature, and oral pigmentation and salivary flow rate were not related to the exposure. The results support our hypothesis that dioxins can interfere with human organogenesis.

Original languageEnglish
Pages (from-to)1313-1318
Number of pages6
JournalEnvironmental Health Perspectives
Volume112
Issue number13
DOIs
Publication statusPublished - Sep 2004

Fingerprint

Dioxins
Aberrations
dioxin
Accidents
accident
Tooth
serum
Serum
Anodontia
Stomatognathic Diseases
Oral Diagnosis
Defects
Sex Education
Organogenesis
Enamels
tooth
defect
Pigmentation
Dental Caries
Periodontal Diseases

Keywords

  • Developmental enamel defect
  • Dioxin
  • Hypodontia
  • Hypomineralization
  • Hypoplasia
  • Seveso
  • TCDD
  • Teeth

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Alaluusua, S., Calderara, P., Gerthoux, P. M., Lukinmaa, P. L., Kovero, O., Needham, L., ... Mocarelli, P. (2004). Developmental dental aberrations after the dioxin accident in Seveso. Environmental Health Perspectives, 112(13), 1313-1318. https://doi.org/10.1289/ehp.6920

Developmental dental aberrations after the dioxin accident in Seveso. / Alaluusua, Satu; Calderara, Pier; Gerthoux, Pier Mario; Lukinmaa, Pirjo Liisa; Kovero, Outi; Needham, Larry; Patterson, Donald G.; Tuomisto, Jouko; Mocarelli, Paolo.

In: Environmental Health Perspectives, Vol. 112, No. 13, 09.2004, p. 1313-1318.

Research output: Contribution to journalArticle

Alaluusua, S, Calderara, P, Gerthoux, PM, Lukinmaa, PL, Kovero, O, Needham, L, Patterson, DG, Tuomisto, J & Mocarelli, P 2004, 'Developmental dental aberrations after the dioxin accident in Seveso', Environmental Health Perspectives, vol. 112, no. 13, pp. 1313-1318. https://doi.org/10.1289/ehp.6920
Alaluusua S, Calderara P, Gerthoux PM, Lukinmaa PL, Kovero O, Needham L et al. Developmental dental aberrations after the dioxin accident in Seveso. Environmental Health Perspectives. 2004 Sep;112(13):1313-1318. https://doi.org/10.1289/ehp.6920
Alaluusua, Satu ; Calderara, Pier ; Gerthoux, Pier Mario ; Lukinmaa, Pirjo Liisa ; Kovero, Outi ; Needham, Larry ; Patterson, Donald G. ; Tuomisto, Jouko ; Mocarelli, Paolo. / Developmental dental aberrations after the dioxin accident in Seveso. In: Environmental Health Perspectives. 2004 ; Vol. 112, No. 13. pp. 1313-1318.
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