Developmental differences of antinociceptive effects of oxotremorine in two inbred strains of mice

F. Pavone, D. Consorti, S. Fagioli

Research output: Contribution to journalArticle

Abstract

During development the C57BL/6 and DBA/2 mouse strains present morphological variations in cholinergic forebrain structures correlated with different behavioral reactivities to cholinergic agents. The present research assessed that these strain-dependent differences are also present in cholinergic-mediated analgesia. The administration of oxotremorine (0.0025, 0.005 and 0.01 mg/kg) to 30- and 60-day-old C57 and DBA mice resulted in dose- age- and strain-dependent analgesia. In particular oxotremorine is more effective in DBA/2 than in C57BL/6 mice and the latter strain showed a significant decrease of analgesic response in adulthood.

Original languageEnglish
Pages (from-to)156-160
Number of pages5
JournalDevelopmental Brain Research
Volume49
Issue number1
DOIs
Publication statusPublished - Sep 1 1989

Keywords

  • Analgesia
  • Mouse
  • Ontogeny
  • Oxotremorine

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

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