Developmental rescue of Drosophila cephalic defects by human Otx genes

T. Nagao, S. Leuzinger, D. Acampora, A. Simeone, R. Finkelstein, H. Reichert, K. Furukubo-Tokunaga

Research output: Contribution to journalArticlepeer-review


The molecular mechanisms of head development are a central question in vertebrate and invertebrate developmental biology. The anteriorly expressed homeobox gene otd in Drosophila and its homolog Otx in mouse are required for the early development of the most anterior part of the body, suggesting that a fundamental genetic program of cephalic development might be conserved between vertebrates and invertebrates. We have examined this hypothesis by introducing the human Otx genes into flies. By inducing expression of the human Otx homologs with a heat shock promoter, we found that both Otx1 and Otx2 functionally complement the cephalic defects of a fly otd mutant through specific activation and inactivation of downstream genes. Combined with previous morphological studies, these results are consistent with the view that a common molecular ground plan of cephalization was invented before the diversification of the protosome and the deuterestome in the course of metazoan evolution.

Original languageEnglish
Pages (from-to)3737-3742
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number7
Publication statusPublished - Mar 31 1998

ASJC Scopus subject areas

  • Genetics
  • General


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