Developments in virus-like particle-based vaccines for HIV

Research output: Contribution to journalArticlepeer-review

Abstract

Virus-like particles (VLPs) hold great promise for the development of effective and affordable vaccines. VLPs, indeed, are suitable for presentation and efficient delivery to antigen-presenting cells of linear as well as conformational antigens. This will ultimately result in a crosspresentation with both MHC class I and II molecules to prime CD4+ T-helper and CD8+ cytotoxic T cells. This review describes an update on the development and use of VLPs as vaccine approaches for HIV.

Original languageEnglish
Pages (from-to)119-127
Number of pages9
JournalExpert Review of Vaccines
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • baculovirus expression vector system
  • broadly neutralizing antibody
  • conformational antigen presentation
  • HIV-VLPs
  • insect cells stable expression
  • vaccines

ASJC Scopus subject areas

  • Immunology
  • Drug Discovery
  • Pharmacology
  • Molecular Medicine

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