Developments in virus-like particle-based vaccines for HIV

Luigi Buonaguro; Maria Tagliamonte; Maria Luisa Visciano; Maria Lina Tornesello; Franco M. Buonaguro

doi:10.1586/erv.12.152

Developments in virus-like particle-based vaccines for HIV

Luigi Buonaguro, Maria Tagliamonte, Maria Luisa Visciano, Maria Lina Tornesello, Franco M. Buonaguro

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

Virus-like particles (VLPs) hold great promise for the development of effective and affordable vaccines. VLPs, indeed, are suitable for presentation and efficient delivery to antigen-presenting cells of linear as well as conformational antigens. This will ultimately result in a crosspresentation with both MHC class I and II molecules to prime CD4⁺ T-helper and CD8⁺ cytotoxic T cells. This review describes an update on the development and use of VLPs as vaccine approaches for HIV.

Original language	English
Pages (from-to)	119-127
Number of pages	9
Journal	Expert Review of Vaccines
Volume	12
Issue number	2
DOIs	https://doi.org/10.1586/erv.12.152
Publication status	Published - Feb 2013

Keywords

baculovirus expression vector system
broadly neutralizing antibody
conformational antigen presentation
HIV-VLPs
insect cells stable expression
vaccines

ASJC Scopus subject areas

Immunology
Drug Discovery
Pharmacology
Molecular Medicine

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10.1586/erv.12.152

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AU - Buonaguro, Franco M.

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Developments in virus-like particle-based vaccines for HIV

Abstract

Keywords

ASJC Scopus subject areas

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