Abstract
Virus-like particles (VLPs) hold great promise for the development of effective and affordable vaccines. VLPs, indeed, are suitable for presentation and efficient delivery to antigen-presenting cells of linear as well as conformational antigens. This will ultimately result in a crosspresentation with both MHC class I and II molecules to prime CD4+ T-helper and CD8+ cytotoxic T cells. This review describes an update on the development and use of VLPs as vaccine approaches for HIV.
| Original language | English |
|---|---|
| Pages (from-to) | 119-127 |
| Number of pages | 9 |
| Journal | Expert Review of Vaccines |
| Volume | 12 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2013 |
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Keywords
- baculovirus expression vector system
- broadly neutralizing antibody
- conformational antigen presentation
- HIV-VLPs
- insect cells stable expression
- vaccines
ASJC Scopus subject areas
- Immunology
- Drug Discovery
- Pharmacology
- Molecular Medicine
Cite this
Developments in virus-like particle-based vaccines for HIV. / Buonaguro, Luigi; Tagliamonte, Maria; Visciano, Maria Luisa; Tornesello, Maria Lina; Buonaguro, Franco M.
In: Expert Review of Vaccines, Vol. 12, No. 2, 02.2013, p. 119-127.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Developments in virus-like particle-based vaccines for HIV
AU - Buonaguro, Luigi
AU - Tagliamonte, Maria
AU - Visciano, Maria Luisa
AU - Tornesello, Maria Lina
AU - Buonaguro, Franco M.
PY - 2013/2
Y1 - 2013/2
N2 - Virus-like particles (VLPs) hold great promise for the development of effective and affordable vaccines. VLPs, indeed, are suitable for presentation and efficient delivery to antigen-presenting cells of linear as well as conformational antigens. This will ultimately result in a crosspresentation with both MHC class I and II molecules to prime CD4+ T-helper and CD8+ cytotoxic T cells. This review describes an update on the development and use of VLPs as vaccine approaches for HIV.
AB - Virus-like particles (VLPs) hold great promise for the development of effective and affordable vaccines. VLPs, indeed, are suitable for presentation and efficient delivery to antigen-presenting cells of linear as well as conformational antigens. This will ultimately result in a crosspresentation with both MHC class I and II molecules to prime CD4+ T-helper and CD8+ cytotoxic T cells. This review describes an update on the development and use of VLPs as vaccine approaches for HIV.
KW - baculovirus expression vector system
KW - broadly neutralizing antibody
KW - conformational antigen presentation
KW - HIV-VLPs
KW - insect cells stable expression
KW - vaccines
UR - http://www.scopus.com/inward/record.url?scp=84874047611&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874047611&partnerID=8YFLogxK
U2 - 10.1586/erv.12.152
DO - 10.1586/erv.12.152
M3 - Article
C2 - 23414404
AN - SCOPUS:84874047611
VL - 12
SP - 119
EP - 127
JO - Expert Review of Vaccines
JF - Expert Review of Vaccines
SN - 1476-0584
IS - 2
ER -