Developments in virus-like particle-based vaccines for HIV

Luigi Buonaguro; Maria Tagliamonte; Maria Luisa Visciano; Maria Lina Tornesello; Franco M. Buonaguro

doi:10.1586/erv.12.152

Developments in virus-like particle-based vaccines for HIV

Luigi Buonaguro, Maria Tagliamonte, Maria Luisa Visciano, Maria Lina Tornesello, Franco M. Buonaguro

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

Virus-like particles (VLPs) hold great promise for the development of effective and affordable vaccines. VLPs, indeed, are suitable for presentation and efficient delivery to antigen-presenting cells of linear as well as conformational antigens. This will ultimately result in a crosspresentation with both MHC class I and II molecules to prime CD4⁺ T-helper and CD8⁺ cytotoxic T cells. This review describes an update on the development and use of VLPs as vaccine approaches for HIV.

Original language	English
Pages (from-to)	119-127
Number of pages	9
Journal	Expert Review of Vaccines
Volume	12
Issue number	2
DOIs	https://doi.org/10.1586/erv.12.152
Publication status	Published - Feb 2013

Keywords

baculovirus expression vector system
broadly neutralizing antibody
conformational antigen presentation
HIV-VLPs
insect cells stable expression
vaccines

ASJC Scopus subject areas

Immunology
Drug Discovery
Pharmacology
Molecular Medicine

Access to Document

10.1586/erv.12.152

Fingerprint Dive into the research topics of 'Developments in virus-like particle-based vaccines for HIV'. Together they form a unique fingerprint.

Cite this

@article{4c82fda5a59546a99427ecc6febe1a9b,

title = "Developments in virus-like particle-based vaccines for HIV",

abstract = "Virus-like particles (VLPs) hold great promise for the development of effective and affordable vaccines. VLPs, indeed, are suitable for presentation and efficient delivery to antigen-presenting cells of linear as well as conformational antigens. This will ultimately result in a crosspresentation with both MHC class I and II molecules to prime CD4+ T-helper and CD8+ cytotoxic T cells. This review describes an update on the development and use of VLPs as vaccine approaches for HIV.",

keywords = "baculovirus expression vector system, broadly neutralizing antibody, conformational antigen presentation, HIV-VLPs, insect cells stable expression, vaccines",

author = "Luigi Buonaguro and Maria Tagliamonte and Visciano, {Maria Luisa} and Tornesello, {Maria Lina} and Buonaguro, {Franco M.}",

year = "2013",

month = feb,

doi = "10.1586/erv.12.152",

language = "English",

volume = "12",

pages = "119--127",

journal = "Expert Review of Vaccines",

issn = "1476-0584",

publisher = "Expert Reviews Ltd.",

number = "2",

}

TY - JOUR

T1 - Developments in virus-like particle-based vaccines for HIV

AU - Buonaguro, Luigi

AU - Tagliamonte, Maria

AU - Visciano, Maria Luisa

AU - Tornesello, Maria Lina

AU - Buonaguro, Franco M.

PY - 2013/2

Y1 - 2013/2

N2 - Virus-like particles (VLPs) hold great promise for the development of effective and affordable vaccines. VLPs, indeed, are suitable for presentation and efficient delivery to antigen-presenting cells of linear as well as conformational antigens. This will ultimately result in a crosspresentation with both MHC class I and II molecules to prime CD4+ T-helper and CD8+ cytotoxic T cells. This review describes an update on the development and use of VLPs as vaccine approaches for HIV.

AB - Virus-like particles (VLPs) hold great promise for the development of effective and affordable vaccines. VLPs, indeed, are suitable for presentation and efficient delivery to antigen-presenting cells of linear as well as conformational antigens. This will ultimately result in a crosspresentation with both MHC class I and II molecules to prime CD4+ T-helper and CD8+ cytotoxic T cells. This review describes an update on the development and use of VLPs as vaccine approaches for HIV.

KW - baculovirus expression vector system

KW - broadly neutralizing antibody

KW - conformational antigen presentation

KW - HIV-VLPs

KW - insect cells stable expression

KW - vaccines

UR - http://www.scopus.com/inward/record.url?scp=84874047611&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874047611&partnerID=8YFLogxK

U2 - 10.1586/erv.12.152

DO - 10.1586/erv.12.152

M3 - Article

C2 - 23414404

AN - SCOPUS:84874047611

VL - 12

SP - 119

EP - 127

JO - Expert Review of Vaccines

JF - Expert Review of Vaccines

SN - 1476-0584

IS - 2

ER -