Abstract
Virus-like particles (VLPs) hold great promise for the development of effective and affordable vaccines. VLPs, indeed, are suitable for presentation and efficient delivery to antigen-presenting cells of linear as well as conformational antigens. This will ultimately result in a crosspresentation with both MHC class I and II molecules to prime CD4+ T-helper and CD8+ cytotoxic T cells. This review describes an update on the development and use of VLPs as vaccine approaches for HIV.
Original language | English |
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Pages (from-to) | 119-127 |
Number of pages | 9 |
Journal | Expert Review of Vaccines |
Volume | 12 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2013 |
Keywords
- baculovirus expression vector system
- broadly neutralizing antibody
- conformational antigen presentation
- HIV-VLPs
- insect cells stable expression
- vaccines
ASJC Scopus subject areas
- Immunology
- Drug Discovery
- Pharmacology
- Molecular Medicine