Dexamethasone implant for macular edema secondary to central retinal vein occlusion in patients younger than 50 years

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the effects of dexamethasone implant for macular edema secondary to central retinal vein occlusion in patients younger than 50 years. Methods: Patients with no previous treatment, macular edema with central foveal thickness .250 mm and best-corrected visual acuity between 1.30 LogMAR and 0.30 LogMAR were prospectively recruited for a 12-month follow-up study. After baseline dexamethasone implant, re-treatment was performed starting from the fourth month if a bestcorrected visual acuity deterioration with central foveal thickness .250 mm occurred after an initial improvement. The primary outcome was the change in the best-corrected visual acuity. Secondary outcomes included the proportion of eyes gaining at least 3 Early Treatment Diabetic Retinopathy Study lines, the change in the central foveal thickness, and the number of treatments. Results: Mean best-corrected visual acuity changed significantly from 0.60 ± 0.38 LogMAR at baseline to 0.43 ± 0.48 at the 12-month examination (P = 0.03). Eight of 16 eyes (50%) gained 3 Early Treatment Diabetic Retinopathy Study lines. Mean central foveal thickness improved significantly from 705 ± 202 mm at baseline to 408 ± 196 mm at 12-month visit (P , 0.001). The patients received a mean of 1.8 ± 0.9 implants with 8/16 eyes and 3/16 receiving 1 and 2 implants, respectively. Conclusion: This present investigation indicates that dexamethasone implant can provide a 3-line improvement in half of the patients younger than 50 years and affected by macular edema secondary to central retinal vein occlusion.

Original languageEnglish
Pages (from-to)1381-1386
Number of pages6
JournalRetina
Volume35
Issue number7
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Ophthalmology

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