Dexamethasone intravitreal implant: An effective adjunctive treatment for recalcitrant noninfectious uveitis

E. Miserocchi, G. Modorati, M. R. Pastore, F. Bandello

Research output: Contribution to journalArticle

Abstract

Purpose: To describe our experience in treating recalcitrant and severe cases of noninfectious posterior uveitis with the 0.7-mg dexamethasone intravitreal implant as adjunctive anti-inflammatory treatment. Procedures: Retrospective study. Twelve patients (8 females; 4 males; 14 affected eyes, 15 implants) with severe recalcitrant uveitis were treated. Patients had an inadequate control of uveitis despite different immunosuppressants and periocular corticosteroid therapy. Primary outcome measures evaluated were: decrease in uveitis activity, improvement in visual acuity, reduction of macular thickness, and occurrence of adverse events. Results: Uveitis activity decreased in all patients after the implant. The mean follow-up time from injection was 9 months. Best-corrected visual acuity improved from 20/80 to 20/40 at the end of follow-up. The mean retinal thickness improved from 496 to 226 μm. Adverse events encountered were: 3 eyes with intraocular pressure elevation, 1 vitreous hemorrhage and 1 subconjunctival hemorrhage. Three patients reduced the daily systemic corticosteroid dosage after treatment. Conclusions: The 0.7-mg dexamethasone intravitreal implant appears to be a novel and promising adjunctive treatment for patients with severe posterior noninfectious uveitis recalcitrant to different immunosuppressive agents.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalOphthalmologica
Volume228
Issue number4
DOIs
Publication statusPublished - Oct 2012

Keywords

  • Corticosteroids
  • Intravitreal dexamethasone
  • Macular edema
  • Uveitis

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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