Dexamethasone prophylaxis in pediatric open heart surgery is associated with increased blood long pentraxin PTX3: Potential clinical implications

Franco Lerzo, Giuseppe Peri, Andrea Doni, Paola Bocca, Fabio Morandi, Angela Pistorio, Anna Maria Carleo, Alberto Mantovani, Vito Pistoia, Ignazia Prigione

Research output: Contribution to journalArticle

Abstract

Glucocorticoid administration before cardiopulmonary bypass (CPB) can reduce the systemic inflammatory response and improve clinical outcome. Long pentraxin PTX3 is a novel inflammatory parameter that could play a protective cardiovascular role by regulating inflammation. Twenty-nine children undergoing open heart surgery were enrolled in the study. Fourteen received dexamethasone (1st dose 1.5mg/Kg i.v. or i.m. the evening before surgery; 2nd dose 1.5mg/kg i.v. before starting bypass) and fifteen children served as control. Blood PTX3, short pentraxin C-reactive protein (CRP), interleukin-1 receptor II (IL-1RII), fibrinogen and partial thromboplastin time (PTT) were assayed at different times. PTX3 levels significantly increased during CPB in dexamethasone-treated (+D) and dexamethasone-untreated (-D) subjects, but were significantly higher in +D than -D patients. CRP levels significantly increased both in +D and -D patients in the postoperative days, with values significantly higher in -D than +D patients. Fibrinogen and PTT values were significantly higher in -D than +D patients in the 1st postoperative day. IL-1RII plasma levels increased in the postoperative period in both groups. Dexamethasone prophylaxis in pediatric patients undergoing CPB for cardiac surgery is associated with a significant increase of blood PTX3 that could contribute to decreasing inflammatory parameters and improving patient clinical outcome.

Original languageEnglish
Article number730828
JournalClinical and Developmental Immunology
Volume2011
DOIs
Publication statusPublished - 2011

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Dexamethasone
Thoracic Surgery
Pediatrics
Cardiopulmonary Bypass
Interleukin-1 Receptors
Partial Thromboplastin Time
C-Reactive Protein
Fibrinogen
Postoperative Period
Glucocorticoids
Inflammation

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

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title = "Dexamethasone prophylaxis in pediatric open heart surgery is associated with increased blood long pentraxin PTX3: Potential clinical implications",
abstract = "Glucocorticoid administration before cardiopulmonary bypass (CPB) can reduce the systemic inflammatory response and improve clinical outcome. Long pentraxin PTX3 is a novel inflammatory parameter that could play a protective cardiovascular role by regulating inflammation. Twenty-nine children undergoing open heart surgery were enrolled in the study. Fourteen received dexamethasone (1st dose 1.5mg/Kg i.v. or i.m. the evening before surgery; 2nd dose 1.5mg/kg i.v. before starting bypass) and fifteen children served as control. Blood PTX3, short pentraxin C-reactive protein (CRP), interleukin-1 receptor II (IL-1RII), fibrinogen and partial thromboplastin time (PTT) were assayed at different times. PTX3 levels significantly increased during CPB in dexamethasone-treated (+D) and dexamethasone-untreated (-D) subjects, but were significantly higher in +D than -D patients. CRP levels significantly increased both in +D and -D patients in the postoperative days, with values significantly higher in -D than +D patients. Fibrinogen and PTT values were significantly higher in -D than +D patients in the 1st postoperative day. IL-1RII plasma levels increased in the postoperative period in both groups. Dexamethasone prophylaxis in pediatric patients undergoing CPB for cardiac surgery is associated with a significant increase of blood PTX3 that could contribute to decreasing inflammatory parameters and improving patient clinical outcome.",
author = "Franco Lerzo and Giuseppe Peri and Andrea Doni and Paola Bocca and Fabio Morandi and Angela Pistorio and Carleo, {Anna Maria} and Alberto Mantovani and Vito Pistoia and Ignazia Prigione",
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T1 - Dexamethasone prophylaxis in pediatric open heart surgery is associated with increased blood long pentraxin PTX3

T2 - Potential clinical implications

AU - Lerzo, Franco

AU - Peri, Giuseppe

AU - Doni, Andrea

AU - Bocca, Paola

AU - Morandi, Fabio

AU - Pistorio, Angela

AU - Carleo, Anna Maria

AU - Mantovani, Alberto

AU - Pistoia, Vito

AU - Prigione, Ignazia

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